Abstract

Transungual drug delivery system is related with the drug delivery over the nail, which is hard because of presence of keratin network into the nail. So in this review mainly concentrated on drug delivery over nail by using nail lacquer formulations, which containing drug on it .The drug delivery via nail plate is done due to association of several diseases into nail, for e.g. onychomycosis, psoriasis, paronychia, onycholysis .These nail diseases are occurred due to presence of several microorganisms like- several fungi, bacteria, parasites and to cure these diseases of nail, several medications should be used. Generally used medications are antifungals- fluconazole, Itraconazole, butenafine, Clotrimazole and also used several antibiotics such as- ciprofloxacin, ofloxacin, levofloxacin. There are several factors such as- Molecular size of the drug, hydrophilicity and lipophilicity of diffusing molecule, nature of vehicle, formulation effect, which affected the delivery of drug over the nail plate. The penetration of the drug molecules should be difficult so for the drug delivery use some penetration enhancers. In the present review main focus on that delivery of drug is done by using formulation in the form of the nail lacquer. Keywords: Medicated nail lacquers, Transungual, nail disorders, antifungals, antibacterials, Penetration enhancers.

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