MEDICATION ADHERENCE STATUS AMONG RHEUMATOID ARTHRITIS PATIENTS
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2016, Vol 8, Issue 7
Abstract
Objective: Rheumatoid arthritis (RA) is a common disease affecting about 5 in 1,000 people in Malaysia. Medication adherence among RA patients can be as low as 30% and non-adherence of disease modifying anti-rheumatic drugs (DMARD) may result in irreversible joint damage. This study aimed to assess adherence rates and to identify potential factors influencing adherence.Methods: A cross-sectional study was conducted at Rheumatology Clinic of a tertiary hospital for 8 w from May to June 2014. A total of 51 RA patients using DMARD were recruited in this study. Researcher-assisted questionnaires were utilized. The study assessed adherence by using Compliance Questionnaire on Rheumatology (CQR5) and data retrieved from pharmacy dispensing records which were measured using Medication Possession Ratio (MPR). Questionnaires to assess beliefs about medicines and satisfaction about medicine information were also used. Subsequently, associations between adherence and demographics, socioeconomics, medication, disease and patient-related factors were determined.Results: The response rate was 75%. Depending on the instruments used, 75% (CQR5) and 60% (MPR) of the patients were adherent to DMARD. Non-adherence was not associated with demographic, socioeconomic and clinical characteristics, satisfaction about medication information and medication concerns. Beliefs about the necessity of medication (r = 0.372; p = 0.007) and necessity-concerns differential (r = 0.439; p = 0.001) were moderately associated with adherence.Conclusion: Patient-related factor was associated with medication adherence in our study population. The necessity-concerns differential of medication beliefs may serve as a possible screening tool for non-adherence or target for adherence-improving intervention among RA patients.Keywords: Rheumatoid arthritis, Medication adherence, Medication beliefs, DMARD
Authors and Affiliations
Ai Sim Wee, Mohd Shahrir Bin Mohamed Said, Adyani Bt Md
Keywords
Related Articles
- EP ID EP576262
- DOI -
- Views 73
- Downloads 0
ANTIOXIDANT AND ANTIBACTERIAL ACTIVITIES OF HYDROALCOHOLIC EXTRACTS FROM ALOYSIA POLYSTACHYA GRISEB MOLDENKE AND LIPPIA TURBINATA GRISEB (VERBENACEAE)
Objective: The aims of this study were to determine polyphenols and flavonoids composition, to evaluate the antioxidant and antibacterial activities and possible antibacterial synergistic effects of hydroalcoholic extrac...
COMPATIBILITY STUDIES OF RASAGILINE MESYLATE WITH SELECTED EXCIPIENTS FOR AN EFFECTIVE SOLID LIPID NANOPARTICLES FORMULATION
Objective: Compatibility study is an important element that should be performed at the early development stage of stable and effective solid dosage form.Methods: The compatibility studies of drug with different polymers...
DEVELOPMENT AND VALIDATION OF UV SPECTROMETRIC METHOD FOR QUANTITATIVE DETERMINATION OF ULIPRISTAL ACETATE
Objective: To develop and validate UV spectrometric method for quantitative determination of ulipristal acetate.Methods: The solvent selected was methanol and detection was carried out at 302 nm.Results: Linearity of the...
THE ESTIMATION OF PHARMACOKINETIC PARAMETERS AND ACCURACY OF THE PREDICTED EQUATION FOR LITHIUM DOSE IN CHILDREN: A PILOT STUDY AT THE YUWAPRASART WAITHAYOPATHUM CHILD PSYCHIATRIC HOSPITAL
Objective: The purpose of the study was to estimate the pharmacokinetic parameters and calculate the precision (%RMSE) of the predicted lithium concentration equation.Methods: This research was studied from blood Lithium...
DESIGN AND EVALUATION OF CONTROLLED-RELEASE OCULAR INSERTS OF BRIMONIDINE-TARTRATE AND TIMOLOL MALEATE
Objective: The current work was attempted to formulate and evaluate a controlled-release matrix-type ocular inserts containing a combination of brimonidine tartrate and timolol maleate, with a view to sustain the drug re...