Memory and learning enhancing activity of different extracts of roots of Vetiveria zizanioides
Journal Title: International Journal of Novel Trends in Pharmaceutical Sciences - Year 2014, Vol 4, Issue 6
Abstract
The present study was undertaken to investigate the effects of Vetiveria zizanioides on learning and memory in mice. Elevated plus maze were employed to test learning and memory. The dose of 500 mg/kg, p.o. of CEVZ, EAEVZ, EEVZ and AEVZ extracts were administered for 28 successive days in separate group of animals. The dose of 500‐mg/kg p.o. of EAEVZ, EEVZ & AEVZ significantly improved learning and memory of mice by decreasing TL in EPM. The result shows CEVZ has no effect on learning and memory and EAEVZ reveal less significant than the EEVZ & AEVZ. Further more, this dose significantly reversed the amnesia induced by scopolamine (0.4 mg/kg, p.o.). To delineate the mechanism by which EA, E, & AEVZ exerts memory and learning, the effect of extracts on whole brain AChE activity was also assessed. Except CEVZ all other extracts decreased whole brain acetyl cholinesterase activity. Here, Piracetam (200 mg/kg, i.p) was used as a standard nootropic agent. Hence Vetiveria zizanioides appears to be a promising candidate for improving memory and it would be worthwhile to explore the potential of this plant in the management of dementia and Alzheimer’s disease.
Authors and Affiliations
C. Velmurugan , SK Shajahan , R Anitha Priyadharshini , S. Vijaya Kumar , B. S. Ashok Kumar , Sujith Thomas
Keywords
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