Meta analysis of the effect of pre-transfusion prophylactic medication on the incidence of adverse reactions to blood transfusion
Journal Title: Chinese Journal of Blood Transfusion - Year 2022, Vol 35, Issue 6
Abstract
Objective To systematically evaluate the correlation between pretransfusion prophylactic medication and the incidence of adverse reactions to blood transfusion(ARBT) by Meta analysis. Methods The relevant literature concerning the effect of pretransfusion prophylactic medication on the incidence of ARBT was searched via Pubmed, Embase, Cochrane Library, CNKI, WanFang Data, and VIP databases, with the date duration from database creation to May 9, 2021. The literature was independently screened by two researchers according to the inclusion and exclusion criteria, relevant data information was extracted, quality evaluation was performed, and Meta analysis was performed using RevMan 5.3 software. Results A total of 36 publications were finally included, involving 137 996 transfusion recipients, of which 62 581 were administered medication before transfusion while 75 415 not. And1742 patients experienced ARBT. Meta analysis results showed that the incidence of ARBT in the pre-transfusion medication group was not statistically different from that in the non-medication group {[RR=0. 88, 95% CI(0.76, 1.01), P>0.05]}, the incidence of febrile reactions was lower in the pre-transfusion group than in the control {[RR=0. 72, 95% CI(0.61, 0.86), P<0.05]}, and the incidence of allergic reactions and hemolytic reactions were not statistically different between the two groups, i. e. [RR=0. 94, 95% CI(0.577, 1.16), P>0.05] vs [RR=0. 24, 95% CI(0.03, 2.13), P>0.05]. Pre-transfusion use of dexamethasone, isoproterenol, and niclosamide had no preventive effect on ARBT, i. e. [RR=0. 91, 95% CI(0.79, 1.04), P>0.05] vs [RR=0. 83, 95% CI(0.68, 1.01), P>0.05] vs [RR=1.21, 95% CI(0.69, 2.10), P>0.05]. Conclusion The incidence of ARBT in the pre-transfusion prophylaxis group was not significantly different from that in the control without considering the patient's history of transfusion, history of ARBT, and use of leukocyte-deleted blood products. The incidence of febrile reactions in the pre-transfusion medication group was lower than that in the control, and further studies in larger randomized controlled trials of higher quality still need to be established due to the suboptimal quality of the included literature and study size. Strictly grasping the indications for blood transfusion, strengthening the monitoring and awareness of ARBT, and using life-saving drugs rationally remain the key clinical concerns.
Authors and Affiliations
Zhongyu KANG, Chun LIU, Wei LIU, Daihong LI
Keywords
Related Articles
- EP ID EP738266
- DOI 10.13303/j.cjbt.issn.1004-549x.2022.06.008
- Views 44
- Downloads 0
Serological characteristics and molecular mechanisms of occult hepatitis B virus infection in blood donors
[Objective] Abstract: Objective To analyze the serological characteristics of occult hepatitis B virus infection (OBI) in blood donors, and to explore the molecular mechanism of HBV S gene mutation in the immune escape o...
Research progress of neonatal low-threshold platelet transfusion strategy
Neonatal thrombocytopenia is one of the common hematological abnormalities in neonates, especially premature infants. Platelet transfusion is an effective method of treating neonatal thrombocytopenia, but its threshold s...
Analysis of common statistical problems in blood transfusion medical research papers
High-quality scientific research papers need the support of correct and rigorous statistical methods. However, many papers in transfusion medicine research have problems with the improper use of statistical methods. This...
Occult hepatitis C virus infection in volunteer blood donors in Shaanxi province
Objective To investigate the prevalence of occult hepatitis C virus infection (OCI) in Shaanxi blood donors and characterize the occult hepatitis C virus in this cohort. Methods Between July and September of 2019, 112, 1...
HPV B19, HAV and HEV infection among voluntary blood donors in Nantong
Objective To evaluate the viability of nucleic acid test(NAT) of human parvovirus B19 (HPV B19), hepatitis A virus (HAV) and hepatitis E virus (HEV) along with routine NAT for voluntary blood donors, and to analyze HPV B...