Metastasis of solid tumors into bone marrow: An experience from a tertiary care centre.
Journal Title: International Journal of Medical Science and Innovative Research (IJMSIR) - Year 2018, Vol 3, Issue 5
Abstract
Bone marrow is one of the common sites to be involved by metastatic tumors. Bone marrow secondaries have been noticed in all types of tumors, the most common being carcinoma prostate, breast and lung in adults and small round cell tumors in paediatric age group. We present a clinicopathological profile of patients with metastastic deposits involving bone marrow over a period of two years. Material and Methods: A total of 625 bone marrow aspirations were performed with biopsy done in 500 cases during the period of 2 years from Jan 2015 to Dec 2017. The patients’ clinical findings, hematological and pathological features were reviewed. 11 cases had secondaries involving marrow. Biopsy was available in all the11 cases. Results: out of 625 cases of bone marrow reported 11 cases had metastatic deposits. 7 cases were picked on aspirate and 4 cases were missed on aspirate because of fibrosis and inadequate sample. These three cases were diagnosed on biopsy. Conclusion: Bone marrow examination is a useful and cheap method for evaluating tumors metastatic to bone marrow. Additionally a clue to the primary site is suggested in cases with unknown primary .IHC on biopsy sections can help us to locate the primary site.
Authors and Affiliations
Tazeen Jeelani
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