Method of Acute Respiratory Infections Prevention in Children with Congenital Heart Diseases
Journal Title: Здоров`я дитини - Year 2014, Vol 7, Issue 58
Abstract
Aim: to study the efficacy and safety of liposomal recombinant interferon alpha-2β in the prevention of acute respiratory infections (ARI) in children with congenital heart disease (CHD). Materials and Methods. In the pre-epidemic period of ARI 31 children 3–12 years old with congenital heart disease (study group) were evaluated the efficacy of a prevention program with liposomal recombinant interferon alpha-2β: 250,000 IU 1 time per day 2 times a week for 1 month (method I). Due to lack of efficacy, later prevention was continued by method II: 250,000 IU 2 times a day for 3 days, then 250,000 IU once a day, 2 times a week for one month. Clinical and laboratory examination (including assessment of the level of lysozyme, lactoferrin and secretory immunoglobulin A) was performed before the preventive effects, on the 30th, 120th, 180th day. Satisfaction with the results of prevention, side effects were assessed. The control group included 20 healthy peers. Results. Initially children with congenital heart disease showed a reduction in oropharyngeal secretions of lysozyme, lactoferrin and secretory immunoglobulin A levels. After a prevention program by method I, we have stated a decrease in the incidence, duration and complications of ARI. Prevention program by method II showed greater efficiency on the above parameters. All children tolerated preventive treatment well, side effects were not deceted. Conclusions. There was a reduction of local immunity parameters in children with congenital heart disease, which increases the risk of ARI morbidity. High efficiency and safety of liposomal recombinant interferon alpha-2β are the basis for its use in children to prevent ARI.
Authors and Affiliations
Ye. V. Bordiuhova
Keywords
Related Articles
- EP ID EP319458
- DOI -
- Views 82
- Downloads 0
On the Problems of Early Diagnosis of Interstitial Lung Diseases in Children (Analysis of Clinical Cases)
The article presents the published data on the prevalence, etiology, pathogenesis, the main clinical manifestations, modern methods of early diagnosis and prognosis of interstitial lung diseases in children. The case of...
Features of Ultrastructural Changes in Colonic Mucosa in Experimental Modeling of Adjuvant Arthritis
The experiment proved the inclusion of compensatory reactions manifested by an increase in the number of functionally active goblet cells, aimed to restorarion of colonic mucosal barrier.
Properties of B.subtilis and Their Use in Clinical Practice
This paper summarizes the data on the properties of Bacillus subtilis and their use in clinical practice. The uniqueness of Subalin is due to the combination of bacilli ability to inhibit the growth of pathogenic and opp...
Preventive and Treatment Measures in Infant Diaper Detmatitis
The paper deals with a problem of infant diaper dermatitis. There were overviewed the literature data about that pathology, the treatment and prevention questions were considered.
Encephalitis, Caused by NMDA-Receptors Antibodies of Neurons
Encephalitis caused by NMDA-receptors antibodies of neurons is a recently determined acute and severe form of encephalitis. Its development is associated with production of antibodies to NR1- and NR2-heteromers of NMDA-r...