MICROANATOMIC STUDY OF HUMAN PANCREATIC ISLETS IN ALCOHOLICS AND NON-ALCOHOLICS- A DESCRIPTIVE COMPARATIVE STUDY
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2018, Vol 7, Issue 49
Abstract
BACKGROUND The islets of Langerhans are an important endocrine gland, which regulate the blood glucose level. The rise in blood glucose level results in diabetes mellitus, an age-old disease which affects all the systems of our body. Now-a-days, an increase in the incidence of diabetes mellitus and pancreatitis is noticed even in younger age groups and in alcoholics. The aim of this study is to find out the microscopic changes in alcoholic islets in different age groups and correlate it with nonalcoholic islets. MATERIALS AND METHODS Thirty six autopsy specimens of alcoholic pancreas and forty specimens of non-alcoholic pancreas were collected from the mortuary of Govt. Medical College, Thiruvananthapuram, Kerala. Histological examination of the glands was done in histology laboratory of Dept. of Anatomy, Govt. Medical College, Thiruvananthapuram, Kerala. For statistical analysis, mean, SD and p-value were determined. Data analysis was performed using SPSS version 16. RESULTS According to the present study, alcoholism produces more changes in pancreatic islets. As age advances, the percentage of beta cells is very much reduced in alcoholic islets. The diameter of islets as well as the diameter of beta cells reduced as age advances in alcoholic islets, but in non-alcoholic islets the diameter of beta cells and islets gradually increase as age advances. CONCLUSION The intake of alcohol leads to degenerative changes in islets and also destruction of beta cells as age advances when compared with the non-alcoholic islets.
Authors and Affiliations
Latha Sreedhar Lekshmi Sreedhar, Suja Robert Joseph Sarasammal, Aswathy Maria Oommen
Keywords
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- EP ID EP549025
- DOI 10.14260/jemds/2018/1162
- Views 88
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