Microbiological profile of bronchoalveolar lavage fluid in patients with chronic respiratory diseases: a tertiary care hospital study
Journal Title: International Journal of Medical Research and Review - Year 2016, Vol 4, Issue 3
Abstract
Objective: Chronic respiratory diseases account for 4 million deaths annually. Infections are most frequent cause of exacerbations. Bronchoalveolar lavage has improved sensitivity and specificity of diagnostic techniques in diagnosis of pulmonary infections. Hospital antibiograms are an important component of detecting and monitoring trends in antimicrobial resistance. Materials and Methods: Retrospectively BAL fluid reports of patients with chronic respiratory diseases undergoing bronchoscopy in KIMS Hospital were collected under aseptic precautions. Antibiotic and antifungal susceptibility testing was done for bacterial isolates and fungal isolates. Results: Among 100 BAL sample cultured for bacterial etiology, 38 samples showed growth, 56 samples showed no growth. Monomicrobial growth of the BAL culture was seen in 34 cases (89%) and polymicrobial growth was seen in 4 (11%). In the antimicrobial susceptibility testing, 100% sensitivity was noted to linezolid, levofloxacin, tetracycline, vancomycin, netilmycin and tobramycin. Pipercillintazobactum and imipenem show sensitivity of 96.2%. Antibiotics showing high resistance pattern were ampicillin (73%) and amoxicillin-clavulanic acid (52.3%). On fungal culture, 27 cases showed growth, of which candida albicans was the most common isolate (37%). Aspergillus accounted for 4 isolates (14.8%), aspergillus niger being predominant. All isolates of candida were 100% susceptible to fluconazole, itraconazole and voriconazole except candida albicans, 10% showed resistance to voriconazole. All isolates of aspergilluis were 100% susceptible to voriconazole and 100% resistance to fluconazole. Conclusion: Bronchoalveolar lavage has improved sensitivity and specificity in diagnosis of pulmonary infections. An updated local antibiogram for each hospital based on local bacteriological patterns and susceptibilities is essential to guide initial empiric therapy.
Authors and Affiliations
Vivek KU, Nutan DM Kumar
Keywords
Related Articles
- EP ID EP227753
- DOI 10.17511
- Views 158
- Downloads 0
Dermatoglyphics patterns in patients suffering from primary amenorrhea and control population
Background: Dermatoglyphics is branch of medical science, which deals with the study of epidermal ridges and their configuration on the palmer region of hand and finger and planter region of foot and toes. Inspection of...
Epidemiological pattern of lung cancer in a tertiary care centre-A prospective observational study
Background: Lung cancer is a leading cause of morbidity and mortality worldwide. An increasing incidence of lung cancer has been observed in India.Aim of the study: To evaluate epidemiological profile oflung cancer in a...
An analysis of ocular features and vision loss at presentation and after treatment in systemic lupus erythematosus in 60 patients
Introduction: Systemic lupus erythematosus (SLE) is a chronic, inflammatory, multisystem autoimmune disease and ocular involvement occurs in several forms. It may be the first indicator of underlying SLE. Early identific...
A rare case of large bilateral epidural hematoma following ventriculoperitoneal shunt: a case report with review of literature
Epidural hematoma discovered several years after ventriculoperitoneal shunt procedure is a rare complication. It may be associated with ventricular decompression due to unregulated lowering of intra-cranial pressure. Thi...
Study of relationship between ABO & Rh blood group and type 2 diabetic mellitus
Background & Objective: The findings of Arid et al, in 1953 regarding association between carcinoma of stomach and B blood group and successively in 1954 regarding association between peptic ulcer and O blood group opene...