Microfracture and Hydrogel Scaffolds for the Treatment of Osteochondral Injuries of the Knee: Clinical Results at 4 Years Follow-Up
Journal Title: Journal of Clinical Medical Research - Year 2021, Vol 2, Issue 1
Abstract
The aim of this study is to evaluate the outcomes of microfracture technique and novel hydrogel scaffold for the treatment of osteochondral injuries of the knee. Forty-one patients affected by grade III and IV osteochondral lesions were treated between 2014 and 2015 with microfractures followed by the injection of a hydrogel scaffold into the defect. All patients have been evaluated pre-operatively, at 6 months, 1, 2, 3 and 4 years postoperatively (WOMAC and VAS scores). The initial total WOMAC score was reduced by 83% at 6 months, 90% at 12 months and 87% at 4 years. The initial VAS score was reduced by 78% at 6 months, 82% at 12 months and 83% at 4 years. All the scores, including total and sub-scores, statistically improved in all followups compared to preoperative data. Our results showed an improvement of clinical outcomes and pain after the microfractures technique has been combined with the use of a hydrogel scaffold, which have been maintained at 4 years follow-up.
Authors and Affiliations
Pipino Gennaro, Borghi Raffaele, Vaccarisi Davide C, Mardones Rodrigo, Giardini Piero, Alessio Giai Via, Indelli Pier Francesco
Sickle Cell Anemia: A Succinct Look into Recently Tested Disease Modifying Interventions
Sickle Cell Anemia (SCA) is a globally prevalent, monogenic, life-threatening blood disorder with a complex pathology that remains obscure. A deepened understanding of the malady in the recent years has led to pharmace...
Alteration of Endocrine Functions and Reproductive Outcome Following Consumption of Edible Crops Grown Around E-Waste Dumpsite Using Albino Wistar Rat Model
Electronic waste (e-waste) is the term used to describe old, end-of-life or discarded appliances using electricity in one form or the other which are destined for reuse, resale, salvage, recycling but most importantly di...
A Closed Loop Two Cycle Audit Assessing the Prescription Practice of Topical Antibiotics for Acute Infective Conjunctivitis in a Primary Care Department
Background: The implementation of guideline recommendations for antibiotics prescription for the management of patients with Acute Infective Conjunctivitis (AIC) in primary care departments remains below par. Objectiv...
Unusual Case of Pyoderma Gangrenosum and Bilateral Ear Changes Secondary to the Use of Cocaine with Levamisole in a Patient with Systemic Lupus Erythematodes
The knowledge of skin as well as ear complications caused by cocaine with levamisole is evolving. We described a patient with primary autoimmune rheumatological disorderSystemic Lupus Erythematosus (SLE) as well as Chro...
Parkinson’s Disease: A Neurodegenerative Disease
Parkinson’s disease is characterized by tremor, stiffness, rigid muscles, bradykinesia, slowness of movement, instability leading to falls, memory and talking difficulties, fatigue, writing modifications (micrography) an...