Microgenderome: An Important Variable for Developing Therapeutic Strategies?
Journal Title: Gastro - Open Journal - Year 2018, Vol 3, Issue 1
Abstract
A close association of microbiota in human health continues to emerge. Microbiota has been implicated in autoimmune disorders such as type I diabetes mellitus, inflammatory bowel disease, rheumatoid arthritis and multiple sclerosis.1 This is pointing out that early-life microbial exposure could be linked to later-life susceptibility to immune-mediated disorders. From the experimental models related to autoimmune disorders, it is known that tissue injury is prevented by alteration in microbiota or in germ-free condition. Therefore, microbial alteration can be beneficial during autoimmune disorders. However, several lines of evidence suggest the role of gender-bias, (regulation of sex-hormones by microbiota) in numerous diseases. This editorial aims to throw light on the novel, emerging triangular relationship between host microbiota, sex hormones (testosterone, progesterone and estrogen) and immune responses cumulatively termed as Microgenderome”.
Authors and Affiliations
Rohit Gundamaraju
Keywords
Related Articles
- EP ID EP555175
- DOI 10.17140/GOJ-3-e005
- Views 151
- Downloads 0
Biphasic Roles of a Small G-Protein, RAC1 in Pancreatic Β-Cell
Glucose-stimulated insulin secretion (GSIS) involves cross talk between small Gproteins and their regulating factors. These interactions results in translocation of insulin-laden granules to the plasma membrane for fusio...
Role of Calcium in Vomiting: Revelations from the Least Shrew Model of Emesis
Cisplatin-like chemotherapeutics cause vomiting via release of multiple neurotransmitters (dopamine, serotonin, or substance P) from the gastrointestinal enterochromaffin cells and/or the brainstem via a Calcium (Ca2+) d...
The Role of Energy Metabolism in Driving Disease Progression in Inflammatory, Hypoxic and Angiogenic Microenvironments
Cellular metabolism plays a crucial role in primed inflammatory, hypoxic and angiogenic microenvironments by supporting disease progression in a range of disease entities. To adapt to fluctuating stress-induced microenvi...
Salvage Cryotherapy for Treatment of Persistent Barrett’s Esophagus
Background: A dysplastic Barrett’s esophagus can lead to cancer if not treated by endoscopic eradication therapy. The current consensus is to eradicate the entire residual Barrett’s esophagus that is visible during endos...
An Observational Chart Review on the Efficacy of Subcutaneous Methotrexate in Mild to moderate Ulcerative Colitis and the Description of Occurrence of Adenomatous Polyps in Afflicted Patients
Ulcerative Colitis (UC) is a type of Inflammatory Bowel Disease (IBD) that affects the large intestine and produces mainly symptoms of abdominal pain and bloody stools. Chart reviews of patients from July 2011 to July 20...