Microglial NLRP3 Activity in Alzheimer's Disease
Journal Title: International Journal of Brain Disorders and Treatment - Year 2017, Vol 3, Issue 1
Abstract
Alzheimer's Disease (AD) is the major disease leading to dementia. This disease is characterized by the presence of β-Amyloid (Aβ) extracellular deposits and neurofibrillary tangles, which induce senile plaques formation. Furthermore, inflammation in AD is mainly mediated by innate immunity-related cells, especially microglia. Recent lines of evidence indicate that inflammatory parameters associated with microglia induce mechanisms of pathogenesis in AD. Although the Nucleotide-Binding Domain and Leucine-Rich Repeat Protein 3 (NLRP3) inflammasome has been reported as an important player in this disease, its activity in the Central Nervous System (CNS) during AD is still poorly understood. In this paper the role of microglial cells and the specific activity of NLRP3 in this cell type during AD are highlighted.
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- EP ID EP349479
- DOI 10.23937/2469-5866/1510019
- Views 152
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