MicroRNAs in Oncology
Journal Title: Global Journal of Biotechnology and Biomaterial Science - Year 2015, Vol 1, Issue 1
Abstract
MicroRNAs (miRNAs) are a family of short non-coding RNA molecules which contain about 18-24 nucleotides. miRNAs play significant regulatory roles in biological processes (cell proliferation, differentiation, survival and motility). miRNAs are essential regulators of coding genes at the post-transcriptional level. The biogenesis of miRNAs is composed of complex processes, and human genome contains approximately two thousand miRNAs (http://www.mirbase.org) [11. Tutar L, Tutar E, Tutar Y (2014) MicroRNAs and cancer; an overview. Curr Pharm Biotechnol 15: 430-437.,22. Calin GA, Croce CM (2006) MicroRNA signatures in human cancers. Nat Rev Cancer 11: 857-866.]. Expression patterns of miRNAs have been found to have links with pathogenesis of many diseases including neurodegenerative diseases, diabetes, cardiovascular diseases, and particularly cancer.
Authors and Affiliations
Tutar Yusuf
Keywords
Related Articles
- EP ID EP555761
- DOI 10.17352/gjbbs.000003
- Views 52
- Downloads 0
Consumption of Aloe vera Mucilage Attenuates Plasma Oxidative Stress and Dyslipidemia in Type 2 Diabetic Rats
This study found that Aloe vera mucilage administration significantly improved biological parameters including lipids composition and oxidative stress in type 2 diabetic rats. Because the mRNA levels of lipogenic genes w...
Biomaterial and Regenerative Medicine Approaches to Restoration of Flexion in Lumbar Herniated Disc
Objective: The systematic objective of this paper is to restore flexion in vertebral bone and to nourish the nucleus pulposus through the approach of biomaterial and regenerative medicine. Method: Studies were made on t...
Use of Comet Assay in Human Lymphocytes as a Molecular Biomarker for Simultaneous Monitoring of Genetic Damage and Genotoxicity in Residents Who Lived Nearby the Santiago River, Mexico, in 2012
Most aquatic and health management authorities need assessing the potential genotoxicity of contaminated effluent to avoid the effects of a lot chemical agents found as environmental contaminants. Previous studies report...
Ruta graveolens Protects Against Isoniazid/Rifampicin-Induced Nephrotoxicity through Modulation of Oxidative Stress and Inflammation
Background and Aim: Drug-induced nephrotoxicity is a renal dyfunction that arises as a result of exposure to nephrotoxic drugs. Anti-tuberculosis therapy can cause nephrotoxicity and permanent kidney damage. The current...
A Protocol for the Computational Design of High Affinity Molecularly Imprinted Polymer Synthetic Receptors
Molecularly imprinted polymer (MIP) nanoparticles, commonly referred to as ‘plastic antibodies’ or synthetic receptors, are polymeric materials with strong affinity and selectivity for a particular chemical target. MIPs...