Microsatellite Instability of Bat-26 and Nr-24among Breast Cancer Patients in Senegal
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2019, Vol 18, Issue 1
Abstract
Microsatellite instability high (MSI-H) tumours are known to have better prognosis than microsatellite stable (MSS) tumours and diagnostic characterization of these tumours reveal differences in clinical, pathological and molecular characteristics.Since diverse populations have variable results for MSI tumours due to varied environmental factors that influencedifferent outcomes, and considering the current success in the exploration of immunotherapy in breast cancer, this study aims to evaluate the microsatellite phenotypes of breast cancer patients in Senegal to better understand the pattern of tumour progression and design therapies for a better treatment outcome. Sixty-five breast tumours were genotyped for microsatellite instability of BAT-26 and NR-24 markers.The result showed MSI in more than 50% of the tumours with variant alleles of 92.5% and 81.4% in BAT-26 and NR-24 respectively. Statistical significance (p-value = 0.041) was observed for SBR grade between MSS and MSI tumours.This study reveals the microsatellite instability phenotype of BAT-26 and NR-24 markers among breast cancer patients in Senegal with a positive correlation between MSI and SBR grade in NR-24. We propose thatNR-24 whichoften show little variation in other studies may be a better marker for the diagnosis of MSI status among breast cancer patients in Senegal
Authors and Affiliations
Aniefiok John Udoakang, Fatimata Mbaye, Mbacke Sembene
Keywords
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- EP ID EP434303
- DOI 10.9790/0853-1801077178.
- Views 55
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