Microwave Irradiated and Conventional Synthesis, Antibacterial Activity Evaluation Studies of Tryptamine-Azole-Fluoroquinolone Conjugates
Journal Title: Archive of Biomedical Science and Engineering - Year 2018, Vol 4, Issue 1
Abstract
Tryptamine was converted to the corresponding 1,2,4-triazole, 1,3,4-oxadiazole, 5-oxo-1,3-thia(oxa)zolidine and 5-(4-chlorophenyl)-1,3-thia(oxa)zole derivatives via several steps. 1,3,4-oxadiazole and 1,2,4-triazoles were then converted to the corresponding Mannich bases containing fluroquinolone core using a one-pot three-components procedure. Conventional and microwave-assisted methods were applied for all syntheses. All the newly synthesized compounds were screened for their antibacterial and most of them were found to have good–moderate antibacterial activity.
Authors and Affiliations
Cebeci Yıldız Uygun, Özdemir Serap Basoglu, Demirbas Ahmet, Karaoglu Sengül Alpay
Keywords
Related Articles
- EP ID EP545642
- DOI 10.17352/abse.000009
- Views 77
- Downloads 0
Coronary Artery Disease Diagnosis Using Supervised Fuzzy C-Means with Differential Search Algorithm-based Generalized Minkowski Metrics
Introduction: Coronary Artery Disease (CAD), one of the leading causes of death, is narrowing the walls of the coronary arteries. Angiography is the most accurate but invasive and costly CAD diagnosis method associated w...
Nanoderm Extracellular Matrix for Reconstructive Surgery Applications
Introduction: Bacterial cellulose (BC) can be used in wide area of applied scientific, especially for tissue regeneration and regenerative medicine, lately, bacterial cellulose mats are used in the treatment of skin cond...
Fabrication and Characterization of HER2 Cell Receptor-Targeted Indocyanine Green-Encapsulated Poly (Lactic-co-Glycolic Acid) Nanoparticles
Introduction: The aim of this study is to fabricate and characterize human epidermal growth factor receptor 2 (HER2)-targeted indocyanine green (ICG)-loaded poly (lactic-co-glycolic acid (PLGA) nanoparticles (HIPNPs). Me...
Deep Brain Stimulation (DBS) and Spinal Cord Stimulation (SCS) – Ethical considerations in the use of Implants and Bio-Medical responsibility at manufacture
Here in this brief we take a quick look into the use of certain biomedical devices and their benefits. At the same time, it is suggested that there are questionable practices by manufacturers, which raise concerns about...
Myocardial Contrast and Stress Echocardiography: New Frontiers
The assessment of myocardial perfusion by echocardiography following intravenous injection of ultrasound contrast agents has proved to be feasible [1]. Low-mechanical index imaging techniques that cause minimal microbubb...