Modern approaches to the treatment of patients with functional constipation

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Modern approaches to the treatment of patients with functional constipation

Journal Title: Сучасна гастроентерологія - Year 2019, Vol 0, Issue 4

Abstract

Objective — to study the efficacy and tolerability of the Lactofor® complex (Ananta Medicare) in outpatients with the verified diagnosis of functional constipation (FC) according to Rome criteria IV. Materials and methods. The study involved 30 outpatients with FC aged 33- 59 years (mean age 47.6 ± 5.9 years), with an average disease duration of 14.9 ± 4.8 years, who were treated with the Lactofor® complex during 28 days: the first 5 days — 2 sachets per day, followed by 1 — 2 sachets per day. The treatment effectiveness was assessed by the dynamics of defecation frequency, the feces according the Bristol scale, the assessment of pain syndrome and flatulence on the visual analog scale, the hydrogen breath test (HBT) with lactulose. Patients’ status and quality of life were assessed with the use of specialized patient questionnaires (PAC-SYM — Patient Assessment of Constipation Symptoms and PAC-QoL — Patient Assessment of Quality of Life questionnaire). Results. The administration of Lactofor® complex to patients with FC promoted the increase ofbowel movements’ frequency (after 28 days of observation, 100 % of patients reported daily bowel movement, lack of tension and incomplete emptying) and normalization of stool character, which was confirmed by an increase in stool scores according to the Bristol scale (2.07 ± 0.4 vs 3.42 ± 0.25; p < 0.05). The effects of Lactofor® complex on the reduction of FC symptomshas been established, in particular, a decrease in the intensity and severity of flatulence in 1.9 times (p < 0.01), as well as painful abdominal syndrome in 2.1 times (p < 0.01). There was also a clear positive trend in PAC-SYM and quality of life (PAC-QoL) indicators. Reduction of HBT at all intervals of the test confirmed the positive effect of the Lactofor® complex on reducing the severity of the bacterial overgrowth syndrome. Conclusions. The administrationof Lactofor® complex to patients with FC promoted the increase of bowel movements’ frequency, normalization of stool character, it resulted in the reduction ofintensity and severity of flatulence, painful abdominal syndrome, as well as improvement of the quality of life.

Authors and Affiliations

I. M. Skrypnyk, O. F. Gopko, I. G. Kryvoruchko

Keywords

functional constipation Lactofor® complex clinical observation

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EP ID EP670162
DOI 10.30978/MG-2019-4-85
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