Modification of Pectin-Glycine with Indomethacin to treatment the wound and inflammations
Journal Title: International Journal of Medical Science and Dental Research - Year 2018, Vol 1, Issue 1
Abstract
This work included preparation new drug polymer as bio adhesive , which have high viscosity and treatment the wounds andexternal inflammation, because it remains inherent to the position of injury fast time, A new bio adhesivepolymer was prepared bymodification of Pectin structure with Glycine as a spacer substituted with drug such as Indomethacinproduced amide polymer. This design carries controlled delivery of therapeutic agents which could release the entrapped drug over an extended period of time due to its biodegradable, nontoxic and slow digesting nature. The prepared drug polymer wsa characterized by FTIR, 1H-NMR spectroscopes, thermo gravimetric analysis TGA and DSC were studied. intrinsic viscosities and Physical properties of all prepared polymer wsa measured, Biological activity was studied for drug polymer,this new adhesive drug biological polymers were applied on different infected mice and wounds, It gave good results and compliance mice infected with a full recovery by a short period of time.
Authors and Affiliations
Firyal Mohammed Ali, Hameed Muthanna Ahmed
Keywords
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- EP ID EP514846
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