Modulation of 6-gingerolin Antidepressant-like Effects: An Investigation of Serotonergic System in Mice Model
Journal Title: GMJ Medicine - Year 2017, Vol 1, Issue 1
Abstract
Background: It has been reported that ginger is involved in serotonergic system. It seems that ginger effect could be attributed to its active compound or gingerol. The present study was conducted to evaluate the effects of gingerol on antidepressant-like effects by investigation of serotonergic system in mice model. Methods: Following pilot study and selection of doses, mice were divided into 4 groups. Receptor antagonists were injected, gingerol was administrated and a trial suspension test was conducted. Results: Administration of gingerol could induce antidepressant-like effect (P<0.001), without induction of changes in spontaneous locomotor activity in the open-field test. Pretreatment of mice with pCPA (preventor of serotonin synthesis), WAY100135 (receptor antagonist), ketanserin (5HT2A receptor antagonist), and cyproheptadine (5HT2 receptor antagonist) prevented the antidepressant-like effect induced by the gingerol (P<0.05). Conclusion: It could be stated that gingerol is involved in antidepressant-like effects through serotonergic system in mice model. It could be recommended to use the gingerol in commercial preparations for prescription as an antidepressant agent.
Authors and Affiliations
Saman Sedighi, Bahram Nasiri, Reza Alipoor, Nasrollah Moradi-kor
Keywords
Related Articles
- EP ID EP44539
- DOI -
- Views 491
- Downloads 0
Carvacrol Alleivated Negative Effects of Diabetes on Inflammation and Oxidation by Modulation in Gene Expression of Inflammatory and Antioxidant System in Diabetic Rat Model
Background: Diabetes has been known as a prevalence disorder and the use of common drugs has been faced many issues with multiple limitations. This study aimed to evaluate the use of carvacrol, as a novel agent, for trea...
Carvacrol and Voluntary Exercise Improved Molecular Profile in Hippocampus of Male Rats Nourished with High-Fat Diet
Background and purpose: High-fat diet (HFD) is one risk factor in some disorders and increases oxidative stress. The use of carvacrol and voluntary exercise can be profitable. This study was thus conducted to evaluate...
Original Article: Anthropometric Study of the Facial Index in the Population of Medical Students in Tehran University of Medical Sciences
Background: Facial anthropometry is useful in individual identifcation and reconsructive surgery. In the present sudy, we aimed to determine the facial characterisic of the Iranian population through anthropometric sud...
Phytochemicals as Safe Agents for Prevention of Cancer: Recent Advances in Cancer Therapy
Cancer has been known as one of the genetic disorder and also as second cause for death in developed countries and/or even in developing countries. It has been estimated to be 26 million new cases of cancer and 17 mill...
Relation Between Novel Markers with Sperm Quality in Obese Rats
Background: Obesity and inflammation stemmed from obesity basically affects fertility and male reproductive system by its negative effect on erectile dysfunction and semen variables. Novel factors could be used to determ...