Modulation of some biochemical complications arising from alloxan-induced diabetic conditions in rats treated with Senna occidentalis leaf extract
Journal Title: Journal of Applied Biology & Biotechnology - Year 2016, Vol 4, Issue 4
Abstract
The present study was designed to evaluate the effects of Senna occidentalis in alloxan-induced diabetic and its complications in Wistar rats. Thirty male Wistar rats with body weight ranging from 180–250 g were selected for the study. Diabetes was induced by single intraperitoneal dose of alloxan injection (150 mg/ kg body weight). Treatment was carried out orally using aqueous and ethanol extracts of Senna occidentalis leaves at 100 mg/kg body weight once daily for 21-days. The fasting blood sugar (FBS), Thiobarbituric acid Reactive Substance (TBARS), alkaline Phosphatase (ALP), alanine aminotransferase (ALT), aspartate aminotransferase (AST), serum bilirubin and full blood count levels were evaluated. The result of the study showed decrease in FBS, TBARS, liver enzymes, bilirubin, platelets (PLT) and white blood count (WBC) as well as increase in lymphocytes (LYM) and red blood count (RBC). The result of study showed to a large extent the effects of Senna occidentalis in the management of some complications resulting from diabetes and its complications.
Authors and Affiliations
Keywords
Related Articles
- EP ID EP455371
- DOI 10.7324/JABB.2016.40405
- Views 103
- Downloads 0
In Vitro Antidiabetic and Anti-oxidant Activities of Methanol Extract of Tinospora Sinensis
In the present study the methanol extracts of Tinospora sinensis Lour (Merr.) was studied for alpha (α)-amylase and alpha (α)-glucosidase inhibition using an in vitro model. The plant extracts were also examined for its...
Identification of heterozygous cases of Bovine leukocyte adhesion deficiency (BLAD) in Indian Holstein crossbred bulls
BLAD is an Autosomal genetic disorder mainly in Holstein Friesian (HF) and HF crossbreds are major concern worldwide as heterozygous (carrier) looks normal and therefore, used for breeding programmes. During the last one...
Aroclor 1254 induced oxidative stress and histopathological changes in mice liver
The toxicity of polychlorinated biphenyls in the living systems is associated with oxidative effects among others. In view of the involvement of antioxidant defense mechanisms in the detoxification of persistent organic...
Isolation and Identification of Chitinase Producing Native Fungi From Saltpan of Puthalam, Kanyakumari District, Tamil Nadu, India
The objective of the present study is isolation and identification of native chitinolytic fungal strains from infected Artemia collected for salt pan of Puthalam, Kanyakumari District, Tamil Nadu. A total of 10 fungi (J1...
Nonconventional induction strategies for production of recombinant human tumor necrosis factor-alpha in Escherichia coli
The present study investigates the production kinetics of recombinant human tumor necrosis factor-alpha (TNF-α) in Escherichia coli under three different nonconventional inducible expression systems, namely, salt, the th...