Molecular studies of non-melanoma skin cancers
Journal Title: Postępy Nauk Medycznych - Year 2012, Vol 25, Issue 10
Abstract
<b>Introduction.</b> Differentiation of keratoacanthoma (KA) from squamous cell carcinoma (SCC) and basal cell carcinoma (BCC) in some cases may be problematic. Molecular studies are conducted to assign the additional diagnostic and prognostic markers and to appoint new therapeutic targets. Metalloproteinases (MMPs) play an important role in tumour progression and metastasis. Their catalytic activity is inhibited by their tissue inhibitors (TIMPs). Because of the importance of metalloproteinases many trials are conducted, including dermatological studies.<br><b>Materials and methods.</b> Tissue samples were obtained from the centre area of BCC, SCC and KA tumours. Transcriptomes of studied samples were appointed with the use expression oligonucletide microarray technique.<br><b>Results. </b>Keratoacanthoma demonstrated considerable molecular similarity to SCC. The group of BCC showed heterogeneity and was divided into two subgroups characterized by different mRNA copy numbers of the MMP10 and MMP2 genes. The transcripts of the gene MMP1 showed a significant increase in all studied groups comparing to controls.<br><b>Conclusions. </b>The increase of MMP10 and decrease of MMP2 mRNA copies could become prognostic markers in patients with cutaneous basal cell carcinoma. Universal potential therapeutic target in non-melanoma skin lesions is metalloproteinase 1 gene.
Authors and Affiliations
Mariola Wyględowska-Kania, Joanna Gola, Anna Fila-Daniłow, Dominika Wcisło-Dziadecka, Ligia Brzezińska-Wcisło, Urszula Mazurek
Keywords
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