MONITORING OF PESTICIDES CHRONIC TOXICITY AMONG EXPOSED WORKERS BY USING EFFECT BIOMARKERS

Journal Title: European Journal of Pharmaceutical and Medical Research - Year 2017, Vol 4, Issue 1

Abstract

Background: Workers who regularly use pesticides at increasing risk of pesticides toxicity. Monitoring of pesticides chronic toxicity is necessary to prevent long term health hazards. This review aimed to compare the validity of cholinesterase biomarkers to that of cytogenetic biomarkers in assessment of pesticides chronic toxicity. Methods: Medline and Cochrane library are searched electronically to collect studies which conducted cholinesterase and cytogenetic biomarkers simultaneously among pesticides exposed workers. A total of 1249 papers have found. After excluding of irrelevant, ineligible, duplicate and very low quality papers, only 16 studies are included in this systematic review. As a gold standard test was absent, we had to validate these biomarkers in order to compare them together. Validation had two phases, phase1 the ability of biomarkers to detect a significant difference between pesticides exposed and non-exposed workers. Phase 2 is purposed to determine a dose-response relationship and to control for confounding. Results: at the study level, the cytogenetic biomarkers have a higher reliability (100%) than cholinesterase biomarkers (75%) for detection of statistically significant difference between chronically exposed and non exposed workers. Furthermore, within studies using cholinesterase biomarkers, erythrocyte cholinesterase (E chE) has higher reliability (78%) than plasma cholinesterase (P AchE) (62%). There is a significant association between duration of exposure and results of cytogenetic biomarkers. This association found to be less evident between duration of exposure and (E chE), and it is absent between duration of exposure and (P AchE). Conclusion: The cytogenetic biomarkers have more reliability than cholinesterase biomarkers in assessment of chronic toxicity caused by pesticides exposure.

Authors and Affiliations

Dr. Hamdi Abdulwahab Alhakimi

Keywords

Related Articles

A CROSS SECTIONAL STUDY OF KNOWLEDGE, ATTITUDE AND PRACTICES OF MENSTRUAL HYGIENE AMONGAU FEMALE STUDENTS

Menstruation and menstrual practices are associated with taboos and socio-cultural restrictions. Good hygienic practices such as the use of sanitary pads and adequate washing of genital area are essential during menstrua...

ANTIMICROBIAL ACTIVITY OF NANOPARTICLES: AN ALTERNATE AGAINST DRUG-RESISTANT PATHOGENIC MICROBES

Antimicrobial agents, considered as miracle drugs, can be obtained from natural sources such as plant or animal or can be produce synthetically. They are used against various pathogens however, the misuse of these drugs...

PREVALENCE AND PATTERN OF SYMPTOMATIC OSTEOARTHRITIS AMONG LOCAL FARMERS OF PANYAM PLATEAU CENTRAL, NIGERIA

Aim: To determine the prevalence and pattern of it affectation of OA in local farmers. Background: Osteoarthritis (OA) is a chronic joint disease causing physical disability to low productivity. The farmers completely de...

EOSINOPHILIC GASTROINTESTINAL DISORDERS: EXPERIENCE OF A TUNISIAN CENTER

Introduction: Eosinophilic gastrointestinal disorders (EGD) are rare chronic digestive pathologies characterized by an eosinophilic infiltration of the digestive tract in the absence of secondary causes for eosinophilia....

ENRICHMENT OF ZINC IN WHEAT THROUGH BIOFORTIFICATION: A REVIEW

Zinc is an important micronutrient in term of biological metabolism, and is gaining a lot of attention globally because of increasing concerns regarding zinc deficiency in humans. The micronutrient is essential for the n...

Download PDF file
  • EP ID EP628291
  • DOI -
  • Views 162
  • Downloads 0

How To Cite

Dr. Hamdi Abdulwahab Alhakimi (2017). MONITORING OF PESTICIDES CHRONIC TOXICITY AMONG EXPOSED WORKERS BY USING EFFECT BIOMARKERS. European Journal of Pharmaceutical and Medical Research, 4(1), 117-124. https://europub.co.uk./articles/-A-628291