MORE Generated Isatinyl Thiazole Derivatives as Anti-Mycobacterium Tuberculosis Agents and dTDP-Rhamnose Inhibitors
Journal Title: Haya: The Saudi Journal of Life Sciences - Year 2018, Vol 3, Issue 10
Abstract
Abstract: In last few decades, though significant progress has been made in the treatment and control strategies of tubercular infections by introducing new diagnostic and monitoring tools and combination therapy, it still continues to be severe problem. Thus with the aim of developing novel molecule with improved potency for treating Mycobacterium tuberculosis H37Rv strain infections and with decreased probability of developing drug resistance, herein we report the synthesis of isatinyl thiazole derivatives, starting from ethyl acetoacetate , by microwave organic reaction enhancement method (MORE) and results of investigations of their antimycobacterial and antimicrobial activities. Many compounds have shown promising activity while others were inactive.
Authors and Affiliations
Rajendra D. Dighe, Pratik D. Patil, Prashant D. Dighe, Rahul Y. Pagar, Rakesh M. Bachhav, Yogesh T. Sonawane, Vinod A. Bairagi
Keywords
Related Articles
- EP ID EP480804
- DOI -
- Views 165
- Downloads 0
Kinetic evidence for improved invertase activity from a novel mutant of Candida fermentati DMS-4
Abstract: Candida fermentati SA3-7, a haploid yeast strain was treated by ultraviolet (UV) radiations and Dimethyl sulphonate (DMS) for enhanced invertase (EC 3.2.1.26) production. The UV induced mutagenesis did not prod...
Neurosyphilis and Intake of Cerebrospinal Fluid (CSF)
Abstract: The Neurosyphilis is the most severe neurological complication of the active syphilis. It puts real diagnostic problems because of the ascendancy of the atypical forms. Our objective is to analyze the clinical...
The Roles Appropriateness and Hierarchy on Cultural Conscience: Therapist’s Perspective
Abstract:This research paper is an attempt to understand how the cultural and social dimensions which operates in the Indian Cultural Context. The research has coined a term called “Cultural Conscience” in order to get a...
Hypoglycemic Activity of Curcuma longa LinnRoot Extracts on Alloxan Induced Diabetic Rats
Abstract: Plants form the main ingredients of medicine in traditional system of healing and have been the source of inspiration for several major pharmaceutical drugs. In spite of great advances of modern scientific medi...
Prevalence of Gastro-Intestinal Parasites in Pigs in Jos South Local Government Area of Plateau State, Nigeria
Abstract: This study was designed to determine the prevalence of gastrointestinal parasites of pigs within three district of Jos South Local Government area of Plateau state, Nigeria. A total of 200 pigs were sampled. Fa...