Morphological characteristics of brain lesions in HIV infection
Journal Title: Медичні перспективи - Year 2018, Vol 23, Issue 1
Abstract
Currently, diseases of the central nervous system are a common cause of death of patients with HIV infection. The article presents results of retrospective analysis of etiotropic structure of 186 lethal cases and typical pathological changes of brain tissue of patients aged 21 to 61 years who had confirmed diagnosis of HIV and died of diseases associated with CNS damage in the Municipal infectious hospital in the city of Dnepr (Ukraine) in the period from 2011 to 2016. The most common causes of death in patients with HIV infection and CNS infection were cerebral tuberculosis (75.0%) including co-infection (n = 35) and meningoencephalitis that developed as a result of yeast fungal (15.6%). In the study of neuropathological processes in the autopsy material of the brain tissue of patients with HIV, various multifocal and diffuse morphological changes have been identified that can be presented in this work in the form of 4 groups: 1) Multiple nonspecific changes associated with both direct action of HIV and co-factors: infection, inflammation, hypoxia, etc., 2) Viral-induced vasculitis with hemorrhages, 3) Subacute aseptic encephalitis, 4) HIV-associated opportunistic infections. General pathomorphological changes in brain tissue are revealed that can cause similarities of clinical manifestations, can complicate differential diagnosis of cerebral lesions of various etiologies, and lead to a divergence of pre and postmortal diagnoses.
Authors and Affiliations
L. R. Shostakovych-Koretskaya, K. Y. Lytvyn, Z. O. Chykarenko, T. V. Usenko, V. O. Logvinenko
Keywords
Related Articles
- EP ID EP274713
- DOI 10.26641/2307-0404.2018.1.124925
- Views 105
- Downloads 0
Features of the cardiovascular system in patients with type 1 diabetes
Lesion of the cardiovascular system in diabetes is the leading cause of mortality in this cohort of patients, it is of particularl importance because current approaches to the treatment of type 1 diabetes and existing in...
Levels of galectin-3, advanced glycated end-products in serum, endothelial function and cardiac hemodynamics in post infarction heart failure in patients with reduced and preserved ejection fraction
Epidemiological studies have reported that the rate of signs and symptoms of heart failure after myocardial infarction is approximately 25%. In addition, approximately 40% of myocardial infarctions are accompanied by lef...
Comparative evaluation of controllability and safety of therapeutic hypothermia in the intensive care of severe traumatic brain injury
The article presents the results of a comparative study of control and safety of two technologies of therapeutic hypothermia in intensive care in patients with TBI: an estimate of the rate of its induction, control of it...
Тhe features of severe community acquired pneumonia
Based on data from a prospective analysis for the year of observation, the article presents information about the features of severe community acquired pneumonia in patients who were hospitalized at the department...
Microbiological and immunological diagnostic criteria for initial degree of generalized periodontitis at the stage of pre X-ray manifestations
The article presents the results of a comparative study of the microbial landscape and violations of local immunity in patients with generalized periodontitis at preclinical-radiological stage of development in 60 patien...