Morphological study of placenta in preeclampsia and its association with natural killer (NK) cells
Journal Title: Medpulse International Journal of Pathology - Year 2019, Vol 9, Issue 2
Abstract
Background and Objectives: Preeclampsia (PE) is a hypertensive disorder of pregnancy characterized by deficient placentation due to inability in remodeling the uterine arteries. A variety of morphological changes are known to occur in placenta in PE. Very few studies have been done in India on NK cells in preeclamptic placenta. Materials and Methods: In the present observational study a total of 76 placentae were collected, of which 38 were from women with diagnosis of PE and 38 placentae from normal term pregnancies. The objectives of the study were to assess the morphological features and expression of decidual NK cells by CD56 immunostain in placentae of patients with PE and to compare them with the placentae from normal term pregnancies. Placentae collected were grossly examined. Hundred villi from minimum four slides were counted and results were recorded. IHC stain was done by CD56 antibody on the tissue block of placental disc containing decidua basalis. NK cells were counted per high power field and scored. Statistical analysis was performed using SPSS software version 22. Mann-Whitney U-test was used to compare the differences between the control group and women with PE. For all statistical analysis P value < 0.05 was considered significant. Results: The mean trimmed weight and diameter of placenta was significantly less in preeclamptic placenta. The significant findings were increased area of maternal surface infarcts, fibrinoid necrosis, occlusion of the fetal artery, syncytial knots, smooth muscle hypertrophy of spiral artery and thickening of basement membrane of villi. There was significant increase in the number of CD56 positive decidual NK cells in PE group. Conclusion: Morphological study of placenta and NK cell status play a vital role in planning and management of future pregnancies.
Authors and Affiliations
M N Jadhav, Lakshmi K S, Kittur S K
Keywords
Related Articles
- EP ID EP457100
- DOI 10.26611/105921
- Views 85
- Downloads 0
Clinicopathological study of non-neoplastic urinary bladder lesions
Background: Non-neoplastic and neoplastic urinary bladder lesions constitute a diverse group of lesions with a wide spectrum of clinical and pathological lesions. Chronic non specific cystitis with histological variants...
Correlation of cytomorphology and cartridge based nucleic acid amplification test (CBNAAT) on fine needle aspirates in the diagnosis of tuberculous lymphadenitis
Background: As per the Global TB Report 2017, India had about a quarter of the world’s TB Cases with a very high incidence of MDR TB and HIV associated TB and high mortality; mostly because of lack of early diagnosis and...
Distribution of ABO and Rhesus blood groups in blood donors at blood bank of tertiary care hospital, Mahabubnagar, Telangana
Background: Blood groups of population are determined genetically by the presence of specific antigens on the erythrocytes (Red blood cells). Blood group antigens are inherited in a mendelian fashion and appear early in...
Validity of sickling test and peripheral blood film method for sickle cell disease screening in tertiary care hospital
Background: Sickle cell disease is one of the most common inherited monogenic disorders, accounting for about 70% of world’s major haemoglobinopathies. The sickle cell genes predominantly seen among the tribal population...
Study of patterns of clinical and histopathological presentation of adnexal neoplasms of skin- A cross sectional study in a tertiary care centre
Background: Adnexal neoplasms of skin are uncommon, include gamut of entities with varied etiological factors, overlapping clinical features, confusing nosology and classification, histomorphological findings and immunoh...