Morphometric assessment of microvessel density by CD105 and CD34 receptor
Journal Title: International Journal of Medical Science and Diagnosis Research (IJMSDR) - Year 2017, Vol 1, Issue 2
Abstract
AIM: To evaluate and compare microvessel density morphometrically using endoglin (CD105) with CD34, a pan-endothelial marker in different histological grades of astrocytoma. Methods: In 61 cases of astrocytoma, the expression of CD105 and CD34 antibody was morphometrically assessed and mean microvessel density (per mm2), total microvessel area (expressed as µm2 per mm2 and as percentage) were calculated and compared in different grades. Ten cases of normal brain tissue retrieved from the archives of department of pathology that had been submitted for postmortem examination were used as control. Results: MVD-CD34 in grade I – IV astrocytoma was 14.5±5.3, 24.1±5.4, 61±8.7 and 89.4±10.7 respectively while MVD-CD105 was 9.40±0.41, 13.97±0.68, 35.72±0.51 and 49.66±1.17 respectively. The total microvessel area (TVA) in grade I – IV astrocytoma using CD34 antibody was 9908±1399.21, 13827±2798.82, 47235±4094.19 and 64840±5656.58 µm2 per mm2 (r=0.95; p<0.05). The total microvessel area (TVA) was 4865.86±40.91, 6721.16±365.33, 22516.14±185.51 and 31458.9±131.45 µm2 per mm2 in grade I – IV astrocytoma respectively on using CD105 antibody. Conclusion: Microvessel density and area determined by CD105 correlated significantly with increasing tumor grades. Thus, CD105 is a superior marker of angiogenesis than CD34 in different grades of astrocytoma. Keywords: Microvessel Density, Angiogenesis, Astrocytoma
Authors and Affiliations
Dr UD Ramaswami
Keywords
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