Moxifloxacin in the treatment of uncomplicated enteric fever
Journal Title: Pakistan Journal of Pharmacology - Year 2011, Vol 28, Issue 1
Abstract
Many drugs have been used for the treatment of enteric fever. Moxifloxacin is a newer fluoroquinolone antibiotic also said to be effective against Salmonella typhi. In order to evaluate its effectiveness in our population, suspected typhoid patients were randomly selected from the OPD’s of JPMC, Department of Medicine and was subjected to blood culture. 40 blood culture positive patients were given Tablet. Moxifloxacin in a dose of 400 mg per day for 10 days. Patients were observed for settlement of fever and / or any adverse effect during this period. Their CBC, ALT & creatinine levels were measured before the start of treatment. They were again subjected to blood culture on day 14, 4 days after the cessation of treatment. Fever settled in all patients between days 5 to 6. Blood cultures were negative in all patients after treatment. It was concluded that Moxifloxacin was effective in treating cases of enteric fever.
Authors and Affiliations
Muhammad Shahzad, Syed Ahmed, Yasmeen Ramzan, Zaidullah Khan
Keywords
Related Articles
- EP ID EP109221
- DOI -
- Views 107
- Downloads 0
Anxiolytic activity of Aloe vera (l.) Burm. F tested in rodents
Aloe Vera was evaluated for CNS activities in mice and different behavioral activities for anxiety and depression were tested on Exploratory activity, Open field test, Swimming – induced Depression test, Stationary Rod,...
Prevalence of HCV genotypes in patients reporting in tertiary health care hospital of Karachi
The present study was designed to see the variables which may affect the conventional treatment outcome by injection interferon in chronic hepatitis “C” patients. Among these variables hepatitis “C” genotype is most impo...
Renal clearance and urinary excretion of ciprofloxacin in lohi sheep
This study was undertaken with objective to investigate the renal clearance and urinary excretion of ciprofloxacin in eight sheep of Lohi breed. Ciprofloxacin was administered at the rate of 5 mg/kg body weight intramusc...
Evaluation of anti A60 IGM for the diagnosis of tuberculosis with elisa method
Evaluation of Anti Tuberculous IgM antibodies for rapid diagnosis of both pulmonary and extra-pulmonary tuberculosis. ELISA assay based on mycobacterial antigen A-60 (Anda Biologicals, France) was used on the sera obtain...
Development of Rp-HPLC method for fexofenadine determination in tablet formulations and development of dissolution method
Fexofenadine hydrochloride is a piperidine derivative. It is indicated to relive signs and symptoms that are related with seasonal allergic rhinitis, such as rhinorrhea, sneezing, nose, throat and itchy eyes. In the pres...