mTOR signaling pathway and mTOR inhibitors in the treatment of cancer
Journal Title: Dicle Tıp Dergisi - Year 2013, Vol 40, Issue 1
Abstract
Mammalian target of rapamycin (mTOR) plays a major role in the regulation of protein translation, cell growth, and metabolism. Three basic signalling pathways that have been described as important in cancer including the phosphatidylinositol 3-kinase (PI3K)/AKT/mTOR kinase cascade, the protein kinase C (PKC) family, and the mitogen- activated protein kinase (MAPK)/Ras signalling cascades. mTOR has been defined as a key kinase acting downstream of the activation of PI3K/AKT. These pathways are frequently deteriorated in cancer, and therefore mTOR inhibition is a important antitumor target. mTOR inhibitors include rapamycin (i.e. sirolimus) and its derivatives; temsirolimus, everolimus, ridaforolimus and deforolimus. mTOR inhibitors has the important potential to provide anticancer activity in many tumor types. Key words: PI3K/AKT/mTOR, mTOR inhibitors, cancer
Authors and Affiliations
Mehmet Küçüköner, Abdurrahman Işıkdoğan
Keywords
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- EP ID EP151330
- DOI doi: 10.5798/diclemedj.0921.2013.01.0248
- Views 117
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