MUCOSAL EOSINOPHILIA- A PROGNOSTIC INDICATOR FOR RECURRENCE IN SINONASAL POLYPOSIS
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2018, Vol 7, Issue 22
Abstract
BACKGROUND With the increasing use and availability of modern investigative modalities for diagnosis of nasal polyposis, an increasing number of cases are being diagnosed routinely. Although, a huge number of these patients are subjected to FESS, the post-operative recurrence free period is unpredictable. Many studies have investigated the association of mucosal eosinophilia and the surgical outcome, few studies have considered the level of tissue eosinophil density required to define mucosal eosinophilia. MATERIALS AND METHODS A prospective observational study from January 2015 - January 2017 with 100 subjects having massive nasal polyposis was conducted. Pre-operatively, specimen was subjected for histopathological examination to comment on the mucosal eosinophilia. Based on this, subjects were classified into two groups and the results were compared. RESULTS In our study, there was significant relation between recurrence of nasal polyposis and mucosal eosinophilia. Out of the 100 subjects involved in the study, 36 patients fell into Group 1 and 64 patients into Group 2. In Group 2, 20 (31%) patients had no recurrence and 44 (69%) patients had recurrence which showed a statistical significance of p-value < 0.05. CONCLUSION The present study found that the level of mucosal eosinophilia of > 10 eosinophils/ HPF had the greatest impact on disease recurrence.
Authors and Affiliations
Niveditha Jayanna, Vineeth Abraham Anchery
Keywords
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