Multiple cerebral aneurysms in lupus
Journal Title: Journal of Medical and Scientific Research - Year 2016, Vol 4, Issue 3
Abstract
Systemic lupus erythematosus (SLE) is an autoimmune chronic multisystemic inflammatory disease of unknown etiology. It has variable course and prognosis. Its clinical manifestations may be constitutional or specific to organ/system involved. Immunological aberrations are the cause for inflammation in various tissues. Nervous system involvement in SLE is common and has diverse clinical and morphological manifestations. Diagnosis of neuropsychiatric involvement remains difficult in SLE. Intracranial vasculitis is rare and results in cerebrovascular accidents (CVA). Young patients are at risk of CVA. Neuropathological features on biopsy include infarcts characterized by fibrinoid necrosis of small intracranial arterioles and capillaries. Fibrinoid necrosis, a common histological finding in SLE, may be responsible for aneurysmal formation. The increased risk and associated mechanisms of SAH in SLE is less well understood. The prevalence of SAH due to rupture of intracranial aneurysms is higher in SLE patients than in the general population, a phenomenon that is thought to be due to focal transmural lupus angitis causing rupture. SAH secondary to aneurysmal bleed is very rare and requires prompt immunosuppression for better outcome.
Authors and Affiliations
Prasanna PV, Rajasekhar L, Varaprasad IR, Habibi S, Paruchuri RK
Keywords
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- EP ID EP602594
- DOI 10.17727/JMSR.2016/4-027
- Views 98
- Downloads 0
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