Mydriasis model in rats as a simple system to evaluate α2-adrenergic activity of the imidazol(in)e compounds.
Journal Title: Pharmacological Reports - Year 2013, Vol 65, Issue 2
Abstract
Imidazol(in)e compounds show the diversity of pharmacological effects including mydriasis, hypotension, sedation, bradycardia and hypothermia. At first it was postulated that these effects are mediated via α2-adrenoceptors exclusively. Clonidine is well known as a model agent to produce pupillary dilation in rats. However, it became obvious later that clonidine-like imidazol(in)e adrenoceptor agonists which produced mydriasis in rats, exhibit also a high affinity for imidazoline I1-receptors. That short report attempts to review the present status of studies to confirm that the mydriasis model in rats can be a selective system to evaluate the α2-adrenergic activity of potential pharmacologically active compounds of imidazol(in)e structure.
Authors and Affiliations
Joanna Raczak-Gutknecht, Teresa Frąckowiak, Antoni Nasal, Roman Kaliszan
Keywords
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