Myeloperoxidase levels predicts the vascular dysfunction in patients with Type 2 Diabetes Mellitus
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2017, Vol 16, Issue 3
Abstract
Background: Myeloperoxidase (MPO) is a heme enzyme which is the major protein in neutrophils and, to a lesser extent, in monocytes. MPO uses H2O2 to generate HOCl that is a potent bactericidal agent, generating reactive oxygen species (ROS). MPO plays an essential part in the innate immune system by catalyzing the production of HOCl. However, MPO has also been implicated as a very harmful agent in an increasing number of inflammatory-mediated disorders Aim: The aim of this study was to evaluate the relationship between MPO with albumin creatinine ratio and to explore possible correlation with HbA1c and Insulin resistance in type 2 diabetic patients. Materials and methods: Sixty type 2 diabetic patients in the age group of 35 to 60 years were selected for this study and 30 age matched healthy individuals were selected as a control group. Serum MPO and Insulin levels were assessed by ELISA method and microalbumin by turbilatex method. Results: The Serum MPO levels were significantly higher in the normoalbuminuric group with diabetes than in the control group, and significantly increased in microalbuminuric patients compared to normoalbuminuric patients. The serum MPO levels were positively correlated with the albumin creatinine ratio (ACR), glycated hemoglobin (HbA1C) and insulin resistance. Conclusion: The serum MPO levels were associated with ACR, HbA1c and Insulin resistance in type 2 diabetic patients and increased levels in normoalbuminuric patients indicates that it could be useful to assess the vascular dysfunction in T2DM patients.
Authors and Affiliations
Santhi . T, John Basha Shaik, Balu Mahendran . K
Keywords
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- EP ID EP598998
- DOI 10.9790/0853-1603083034.
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