N-Acetyl Cysteine in treatment of COPD
Journal Title: IP Indian Journal of Immunology and Respiratory Medicine - Year 2018, Vol 3, Issue 3
Abstract
Introduction In COPD excess expectoration secondary to tracheobronchial secretions contributes to symptoms airflow obstruction and is diagnostic criterion It also causes increased mortality risk of hospitalizations and accelerated decline in FEV1 Nacetylcysteine NAC helps in liquefying mucus and DNA via disruption of disulfide bonds and has antioxidant effectsAims Evaluate addon effect of NAC on clinicalphysiological parameters in COPD patients treated according to GOLD guidelinesMaterial and Methods Single labeled randomized parallel group prospective Observational study In 120 stable COPD patients Modified medical research council MMRC dyspnoea score COPD Assessment test CAT score number of exacerbations and hospitalizations in the last year were recorded and were randomized into 2 groups of 60 each Group A received NAC 600mg twice daily along with standard treatment Group B received standard treatment only Mean and Standard Deviation was compared between groups using unpaired ttest After 1 year changes in above parameters were reassessedStatistical Analysis Unpaired ttest and chi square test were used Statistical significance was set at Results MMRC score reduced from 337 study group to 291 difference being 046 and in control from 337 to 118 difference of 022 and p value of p
Authors and Affiliations
Aleemuddin MM, Raheem Fatima, Mohsin Dr, Ashfaq Hasan
Keywords
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- EP ID EP490608
- DOI 10.18231/2581-4222.2018.0035
- Views 81
- Downloads 0
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