N-PHENYLBENZAMIDE SYNTHESIS BY NUCLEOPHILIC SUBSTITUTION WITH 1,3-DIPHENYLTHIOUREA
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2015, Vol 7, Issue 3
Abstract
Objective: N-phenylbenzamides are important and biologically active compounds. N-phenylbenzamides have been synthesized by some routes. An attempt has been made to find out the new route to synthesize N-phenylbenzamides.Methods: The reaction was carried out by reacting substituted benzoyl chlorides with 1,3-diphenylthiourea in the presence of triethylamine in THF at 70 °C. After 4hr the product was purified and identified.Results: An excellent and pure yield of N-phenylbenzamides was obtained by reacting substituted benzoyl chlorides with 1,3-diphenylthiourea. The proposed mechanism follows imino alcohol-amide tautomerism and suggests the involvement of rearrangement intermediate.Conclusion: 1,3-diphenylthiourea is inexpensive commodity chemical and it is found to be the useful reagent for the direct conversion to N-phenylbenzamide. The proposed mechanism follows imino alcohol-amide tautomerism and suggests the involvement of rearrangement intermediate. The synthesis gave pure, high yield, and the one and only isolated product. Â
Authors and Affiliations
Indah Purnama Sary, Siswandono Siswodihardjo, Tutuk Budiati
Keywords
Related Articles
- EP ID EP579018
- DOI -
- Views 78
- Downloads 0
DESIGN, SYNTHESIS AND MOLECULAR DOCKING STUDY OF HYBRID QUINOLINE-4-YL-OXADIAZOLES/OXATHIADIAZOLES AS POTENT ANTIFUNGAL AGENTS
Objective: The aim of the present work was to design and synthesize hybrid quinoline-4-yl-oxadiazoles/oxathiadiazole derivatives and evaluate them for in vitro antifungal activity against human disease causing pathogens....
EFFECT OF NON-VOLATILE SOLVENT AND EXCIPIENT RATIO ON FLOW AND CONSOLIDATION PROPERTIES OF POWDER BLEND FOR LIQUISOLID COMPACTS
Objective: To study the effect of non-volatile solvent and excipient ratio on flow and consolidation properties of powder blend for liquisolid compacts.Methods: The effect of non-volatile solvent and excipient ratio on f...
SYNTHESIS OF MESOPOROUS SILICA NANOPARTICLES AND DRUG LOADING FOR GRAM POSITIVE AND GRAM NEGATIVE BACTERIA
Objective: To synthesize mesoporous silica nanoparticles using the sol-gel method and to determine the antibacterial activity of mesoporous silica nanoparticles and tetracycline loaded mesoporous silica nanoparticles.Met...
MULTIPLE TREATMENT OF EREMURUS HIMALAICUS EXTRACTS AMELIORATES CARBON TETRACHLORIDE INDUCED LIVER INJURY IN RATS
Objective: Eremurus himalaicus Baker, an edible herb of North Western Himalayas, has not been scientifically assessed for hepatoprotective potential. The ethyl acetate extract (EHE), methanolic extract (EHM) and aqueous...
DRUG USE EVALUATION OF DIABETES MELLITUS IN NON-HOSPITALIZED PATIENTS
Objective: As irrational drug administration in these patients can increase the overall burden of Diabetes Mellitus (DM) on the health system in different societies, we decided to investigate the patterns of antidiabetic...