NASAL/BUBBLE CPAP VERSUS MECHANICAL VENTILATION FOR RESPIRATORY SUPPORT IN PRETERM INFANTS AT BIRTH
Journal Title: European Journal of Biomedical and Pharmaceutical Sciences - Year 2018, Vol 5, Issue 9
Abstract
Background: Preterm neonates are at risk of respiratory distress syndrome (RDS) and require mechanical ventilation to keep them alive. However, there are complications associated with mechanical ventilation which are mostly iatrogenic. Of these, Ventilator-Induced Lung Injury (VILI) has long been recognized as a contributor to the development of bronchopulmonary dysplasia (BPD) or chronic lung disease (CLD). There has been increased interest in continuous positive airway pressure (CPAP) as a primary ‘gentler’ mode of respiratory support in RDS to improve mortality and reduce the occurrence of long-term respiratory morbidity. Methods: We performed a retrospective study, involving neonates who were born between 24 weeks 0 days and 36 weeks 6 days of gestation. Neonates were managed by CPAP or mechanical ventilation strategy. The primary outcomes were death, bronchopulmonary dysplasia (BPD), and duration of hospital stay. The secondary outcomes were patent ductus arteriosus (PDA), necrotizing enterocolitis (NEC), and pneumothorax. Results: A total of 250 neonates were enrolled in the study. The rates of the primary outcomes (death, BPD, and duration of hospital stay) and part of the secondary outcomes (PDA and NEC) were statistically significant between the two strategies (CPAP and mechanical ventilation). Pneumothorax didn't show any statistically significance difference between the two groups. Neonates who were managed by CPAP strategy, showed lower incidence of BPD (P-value= 0.046), PDA (P-value=0.016), NEC (P-value=0.001), and death (P-value <0.0001), and shorter duration of hospital stay (P-value<0.0001). Conclusion: The result of this study supports consideration of CPAP as an alternative strategy to intubation and mechanical ventilation in preterm neonates for respiratory support at birth.
Authors and Affiliations
Dr. Sirin Mneimneh
Keywords
Related Articles
- EP ID EP638359
- DOI -
- Views 146
- Downloads 0
RAISED DOSAGE OF CASHEW LEAVES EXTRACT (ANACARDIUM OCCIDENTALE) MORE POTENT THAN OMEPRAZOLE IN GASTRIC SECRETION ULCER TREATMENT
Effects of ethanolic extract of cashew leaves in thirty six (36) male and female albino rats with induced gastric ulcer were investigated for 14 days. The animals were divided into six (6) groups with six animals in each...
ANTIHYPERLIPIDEMIC ACTIVITY OF COCCINIA GRANDIS ON HIGH FAT DIET INDUCED WISTAR ALBINO RATS
The aim of conducting this study is to investigate the antihyperlipidemic activity of the ethanolic leaf extracts of Coccinia grandis in High-fat diet (HFD) fed rats to rationalize its primitive medicinal contemplation....
NEONATAL CARE UNIT ANTIBIOTIC THERAPY IN THE CHILDREN WELFARE TEACHING HOSPITAL
Background: Antibiotics are commonly used medication in neonatal care units (NCU) as sepsis regard the main cause of neonatal morbidity and mortality, especially in preterm infants. Consequently, practitioners in NCU hav...
A COMPARATIVE STUDY OF THE IMPACT OF CONTINUOUS AND BATCH PROCESSES ON THE DIASTATIC (THERAPEUTIC) ACTIVITIES OF TSIRO
The diastatic indices (TSS, R-index, pH and water absorption capacity) of malted rice grains (24 – 120h sprouting, giving samples A – E respectively for each day) were measured after mixing each with 10g of whole maize f...
OVERVIEW OF HEPATITIS B SURFACE ANTIGEN INCIDENCE AMONG PREGNANT WOMEN IN KING HUSSEIN MEDICAL CENTRE AND PRINCE HASHEM HOSPITAL
Objective: To determine the prevalence of hepatitis B surface antigen among pregnant women presenting to antenatal care clinic in Prince Hashem Hospital in Zarqa city and King Hussein Medical Centre (KHMC) in Amman, Jord...