Effects of various excipients on tizanidine hydrochloride tablets prepared by direct compression
Journal Title: Pakistan Journal of Pharmaceutical Sciences - Year 2014, Vol 27, Issue 5
Abstract
This study was conducted to assess the effects of various excipients in 10 different Tizanidine hydrochloride tablet dosage forms that were prepared by direct compression method (DC). Various excipients are available for DC method; we selected those excipients that are used commonly in tablet manufacturing. The excipients used included lactose anhydrous, di-basic calcium phosphate anhydrous, starch, talc, sodium carboxy methyl cellulose, polyvinyl pyrrolidone (PVP), silicon dioxide (Aerosil), stearic acid, magnesium stearate and microcrystalline cellulose (Avicel). These tablets were then evaluated by performing different pharmacopoeial and non-pharmacopoeial tests (i.e. diameter, hardness, thickness, weight variation, disintegration and assay). It was observed that Formulations B, D and H of Tizanidine hydrochloride gave best results within USP specified limits for the tests employed among all the formulations whereas Formulations F and G showed poor friability, disintegration and dissolution profiles rendering starch in combination of talc and sodium carboxy- methyl cellulose unsuitable for Tizanidine hydrochloride tablet formulations. With the present approach, more studies can be designed using other active ingredients and excipients to get an optimal and cost effective product.
Authors and Affiliations
Lubna Ghazal Khan , , Nighat Razvi , Fakhsheena Anjum , Saeed Ahmed Siddiqui , Sana Ghayas
Keywords
Related Articles
- EP ID EP142345
- DOI -
- Views 112
- Downloads 0
The correlation between the Glycated hemoglobin (HbA1c) in non-diabetics and cardiovascular risk factors
This study aimed to discuss the relativity between the glycated hemoglobin (HbA1c) in non-diabetics and cardiovascular risk factors and definite the significance of predicting the cardiovascular risk factors throug...
Phenolic composition and antioxidant activity of thedifferent extracts from Thymus longicaulis C Presl. subsp. longicaulis var. longicaulis and T. longicaulis C. Presl. su bsp. longicaulis var. subisophyllus growing in Turkey
The objectives of the present study were to investigate the phenolic composition and in vitro antioxidant capacities of the infusions and different extracts of two Thymus taxa: Thymus longicaulis C. Presl. subsp. l...
Adrenaline improves endurance of rabbit gastrocnemius: A study with continuous high frequency stimulation
Beta adrenoceptor agonists are well known for their potentiating effects on peak twitch and tetanic tension and defatiguing effects on skeletal muscles. Adrenaline (ADR) is one of these agonist which is known for i...
The effects of gabapentin on severity of post spinal anesthesia headache
Spinal anesthesia is a common anesthesia method and post dural puncture headache (PDPH) is one of its most common adverse effects. Gabapentin is a popular anticonvulsant drug that has been used as an oral nonopioid...
Antibacterial, antioxidant, anti-cholinesterase potential and flavonol glycosides of Biscutella raphanifolia (Brassicaceae)
Different extracts of the aerial parts of Biscutella raphanifolia (Brassicaceae), which has not been the subject of any study, were screened for the phytochemical content, anti-microbial, antioxidant and anti-choli...