ORAL CLONIDINE PREMEDICATION: A COMPARATIVE STUDY WITH A PLACEBO IN ATTENUATING HEMODYNAMIC RESPONSES TO LARYNGOSCOPY AND INTUBATION
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2015, Vol 4, Issue 32
Abstract
[b] BACKGROUND[/b]: Sympathetic response associated with laryngoscopy and endotracheal intubation is a potential cause for a number of complications especially in patients with cardiovascular compromise. The aim of our study was to evaluate and study the efficiency of oral Clonidine premedication in this respect as compared with a placebo. [b]METHODS[/b]: 100 surgical patients of either sex of physical status ASA I/II were randomly divided into two groups. Group I, who received oral Clonidine tablet 0. 003mg (3µg) /kg 90 minutes before surgery and group II, who received oral Ranitidine tablet 150mg 90 minutes before surgery. Basal parameters like HR, SBP, DBP were measured before premedication and for 90 minutes after; scoring was done for sedation, anxiolysis and antisialogogue effects 90 minutes after premedication. [b]RESULT[/b]: Oral Clonidine showed statistically significant attenuation of haemodynamic responses to laryngoscopy and intubation and in addition it was found to have good sedative, anxiolytic effect as comared with placebo. [b]CONCLUSION[/b]: we conclude that oral Clonidine premedication with dose of 3µg/kg is highly effective in attenuating hemodynamic response to laryngoscopy and intubation.
Authors and Affiliations
Gurudatta K. N, Ashwini S
Keywords
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- EP ID EP106489
- DOI 10.14260/jemds/2015/808
- Views 115
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