A Comparison of GFR by Cockcroft-Gault Equations and Gates method for estimating Glomerular Filtration Rate in Chronic Kidney Disease Patients.
Journal Title: IOSR Journal of Pharmacy (IOSRPHR) - Year 2015, Vol 5, Issue 2
Abstract
The gamma camera uptake method with 99m Technetium labeled Diethylene Triamine Penta Acetic acid (Tc-DTPA) is simple and less time consuming for determination of glomerular filtration rate (GFR).Predicted creatinine clearance methods were compared with Gates method using 99m Tc-DTPA formeasurement of GFR.99mTc-DTPA renography was performed on 92 patients (72 men and 20 women, age range being 21 to 72 years) with wide range of renal function. The GFR was determined simultaneously by two methods,(a)Gamma camera uptake (Gates),(b)Predicted creatinine clearance methods: (i) Cockcroft-Gault (CG) and (ii) Modification of Diet in Renal Disease (MDRD). The Gamma camera uptake method was chosen as a reference. For GFR <15ml/min/1.73m2, there were no formulae correlated with isotopic GFR (iGFR). The MDRD equation was found to correlated with iGFR when GFR ranges16-29 ml/min/1.73m2 (P=0.0004) and GFR ranged from 30-59 ml/min/1.73m2 (P=0.0001). The CG formula was correlated with iGFR (P=0.0172) when GFR ranges from 60-89 ml/min/1.73m2.CG estimate of GFR predicts renal function in patients with chronic kidney disease (CKD) in normal GFR range (>60 ml/min/1.73m2). The MDRD equation estimated that the GFR predicts renal function in patients with CKD when GFR range from (16 to 60 ml/min/1.73m2). There are no formulae that predicts GFR<15 ml/min/1.73m2.
Authors and Affiliations
DR. SRABONI SEN , DR. ARUNA BHATTACHARYA
Keywords
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