A Comparison of GFR by Cockcroft-Gault Equations and Gates method for estimating Glomerular Filtration Rate in Chronic Kidney Disease Patients.
Journal Title: IOSR Journal of Pharmacy (IOSRPHR) - Year 2015, Vol 5, Issue 2
Abstract
The gamma camera uptake method with 99m Technetium labeled Diethylene Triamine Penta Acetic acid (Tc-DTPA) is simple and less time consuming for determination of glomerular filtration rate (GFR).Predicted creatinine clearance methods were compared with Gates method using 99m Tc-DTPA formeasurement of GFR.99mTc-DTPA renography was performed on 92 patients (72 men and 20 women, age range being 21 to 72 years) with wide range of renal function. The GFR was determined simultaneously by two methods,(a)Gamma camera uptake (Gates),(b)Predicted creatinine clearance methods: (i) Cockcroft-Gault (CG) and (ii) Modification of Diet in Renal Disease (MDRD). The Gamma camera uptake method was chosen as a reference. For GFR <15ml/min/1.73m2, there were no formulae correlated with isotopic GFR (iGFR). The MDRD equation was found to correlated with iGFR when GFR ranges16-29 ml/min/1.73m2 (P=0.0004) and GFR ranged from 30-59 ml/min/1.73m2 (P=0.0001). The CG formula was correlated with iGFR (P=0.0172) when GFR ranges from 60-89 ml/min/1.73m2.CG estimate of GFR predicts renal function in patients with chronic kidney disease (CKD) in normal GFR range (>60 ml/min/1.73m2). The MDRD equation estimated that the GFR predicts renal function in patients with CKD when GFR range from (16 to 60 ml/min/1.73m2). There are no formulae that predicts GFR<15 ml/min/1.73m2.
Authors and Affiliations
DR. SRABONI SEN , DR. ARUNA BHATTACHARYA
Keywords
Related Articles
- EP ID EP158466
- DOI -
- Views 114
- Downloads 0
[b]COMBINED TITRI METRIC AND POLARI METRIC METHODS FOR DETERMINATION OF MALTOSE IN MALTING BARLEY[/b]
Hepatoprotective Activity of Flavonoids Purified and Ethanolic Extract from Iraqi Propolis Against Carbon tetrachloride-Induced Liver Damage In Male Mice
The present study aims to investigatethe antioxidant activity of flavonoids purified and methanolic extract from propolis on male mice compared to that caused by carbon tetrachloride as a hepatotoxic model by measu...
Acyclovir Induced Acute Kidney Injury In Acute Meningitis Patient: A Case Report Highlights the Concurrence Of AKI Risk Factors And The Neutropenic Effect Of Ticlopidine
Nephrotoxicity is one of the challenging side effects of acyclovir use in clinical practice. The Concomitant use of other nephrotoxic antibiotics, in addition to patient's risk factors, can trigger acyclovir indu...
Antimicrobial Potential and In Vitro Cytotoxicity Study of Tabernaemontana Divaricata (L.) Stem Bark Extract Against HEK 293 Cell Line
Resistance of antibiotics against pathogenic microbes is a growing clinical concern, and the spread of resistant strains worldwide has been discombobulating public health. The ability of most infectious microbes evolving...
Biodegradation of phenol by aspergillus Niger
Phenolic compounds are hazardous pollutants that are toxic to the natural ecosystem at very low concentration Biodegradation is the process by which organic substances are broken down into smaller compounds by th...