A Review on Anti microbial Activity of 4-thiazolidinone Derivatives
Journal Title: International Journal of Research in Pharmacy and Science - Year 2011, Vol 1, Issue 1
Abstract
The practice of medicinal chemistry is devoted to the discovery and development of new agents for treating diseases. The process of establishing a new drug is exceedingly complex and involves talents of people from variety of disciplines. An important aspect of medicinal chemistry has been to establish a relationship between chemical and biological activity. It has been established that half of the therapeutic agents consist of heterocyclic compound. The heterocyclic ring comprises the core of the active moiety or pharmacophore. An especially big attention is given to sulphur and nitrogen containing heterocyclic compounds, as they possess a broad spectrum of biological activity, and are used in various fields of pharmacy. It is well known that a number of heterocyclic compounds containing nitrogen, oxygen and sulphur exhibit a wide variety of biological activity. Compounds carrying the thiazolidinone ring have reported to demonstrate a wide range of pharmacological activities which include anti microbial antifungal activity, antitubercular antitumor, antidiabetic activity anti inflammatory, anticonvulsant. Until the seventies of the 20th century, fungal infections were rather easily cured and the need for new antifungal drugs was low. Low choice of antifungal preparations, toxicity, and limited spectrum of action as well as risk of resistant strains prove the need of new effective medicines for systemic fungal diseases. Therefore, it is necessary to seek for new and less toxic antifungal compounds. Fungemia is an important cause of morbidity and mortality in hospitalized patients. Moreover, the emergence of resistance to currently available antifungals is of great concern and has led to susceptibility testing of new antifungal agents. To investigate the activity profile of thiazolidinone derivatives bearing different substituent at 2, 3 and 5 position have been prepared.
Authors and Affiliations
Vinay Vijay, Lakshika Khurana
Keywords
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