Analgesic, Anti-inflammatory and CNS depressant effects of Atropa belladonna
Journal Title: Pakistan Journal of Pharmaceutical Sciences - Year 2014, Vol 27, Issue 6
Abstract
The present study was carried out to investigate, in vivo, analgesic, anti-inflammatory and neuro-pharmacological activities of the methanolic extract of Atropa belladonna. The analgesic activity was measured by acetic acid induced writhing inhibition test. The neuro-pharmacological activities were evaluated by open field, rearing test, cage cross, swim test, head dip and traction tests. The anti-inflammatory activity was assessed by formalin induce inflammation on hind paw. The extract showed highly significant (p<0.001) analgesic activity with % inhibitions of writhing response at doses 100 and 300mg/kg body weight were 28.5% and 57.1%, respectively. The extract at both doses showed significant (p<0.05) sedative effect in-cage cross test and highly significance value (p<0.001) in high dose. In-open field test, the extract showed significant (P<0.05) anxiolytic activity at higher dose whereas in rearing test activity shows significant p-value at both doses. The extract also showed significant value for anti-inflammatory activity. The findings of the study clearly indicated the presence of significant analgesic, neuro-pharmacological and anti-inflammatory properties of the plant, which demands further investigation including, compounds isolation.
Authors and Affiliations
Farah Owais , Sohail Anwar , Farah-Saeed , Shafi Muhammad , Saiqa Ishtiaque , Omair Mohiuddin
Keywords
Related Articles
- EP ID EP105908
- DOI -
- Views 86
- Downloads 0
Carboxypeptidase-B from Bubalus bubalis pancreas: Purification, properties and MALDI-TOF monitored activation of proinsulin
Carboxypeptidase-B (E.C 3.4.17.2) catalyzes the hydrolysis of peptides and esters at C-terminus of arginine and lysine residues. Our study describes the large scale purification, N-terminal sequence analysis and ph...
A simple and convenient method for the simultaneous in vitro study of metformin and glimepiride tablets
: A simple and convenient method was developed for the simultaneous determination of metformin HCl and glimepiride in tablet dosage form of different pharmaceuticals companies. This method was validated and proved...
Phytochemical analysis of Hibiscus caesius using high performance liquid chromatography coupled with mass spectrometry
Various species in genus Hibiscus are traditionally known for their therapeutic attributes. The present study focused on the phytochemical analysis of a rather unexplored species Hibiscus caesius (H. caesius), usin...
In vitro release of ketoprofen suppositories using the USP basket and the flow-through cell dissolution methods
In order to study the release characteristics of ketoprofen suppositories under the hydrodynamic environment generated by USP Apparatus 1 and 4, the dissolution profiles of the Mexican reference product (100 mg) we...
Traditional herbal healers “Hakims” use various plants of the Cholistan desert, Pakistan for treating a number of infectious and non-infectious diseases. However, there has never been a scientific validation of the...