ANALYTICAL TECHNIQUES FOR THE ESTIMATION OF MIRTAZAPINE IN BULK AND PHARMACEUTICAL DOSAGE FORMS: A REVIEW
Journal Title: Int J of Pharm Res & Analy - Year 2016, Vol 6, Issue 1
Abstract
ABSTRACTMirtazapine (MRZ) has a piperazinoazepine structure {1,2,3,4,10,14b-hexahydro-2- methylpyrazino [2,1-a]-pyrido[2,3-c][2] benzazepine}. It belongs to the class of noradrenergic and specific serotonergic inhibitor antidepressants (NASSA) .MRZ increases the central noradrenergic and serotonergic activity by blocking α2 adrenergic receptors. MRZ also acts as anantagonist of postsynaptic serotonin type 2 (5-HT2) and type 3 (5-HT3) drug has a different mechanism compared to most ofthe second generation antidepressants, and it is used to treat generalized anxiety , obsessive–compulsive , and post traumaticstress disorders . It has a high affinity for histamine H1 receptors: Literature survey reveals that Mirtazapine is estimatedindividually by Spectrometric ,RP-HPLC, LC/MS/MS ,Force degradation & Stability indicating RP-HPLC,CapallaryEclectrophorosis,HPLC-Fluorescence, LC-UV-LC-MS,Quantification by HPLC-ESI-MS/MS,Determination ofspectrofluoremetric and CZE.Keywords: Mirtazapine,RP-HPLC,LC/MS/MS, Spectrometric, Spectroflurometry, Capillary Electrophorosis. LC-UV-LC-MS,HPLC-ESI-MS/MS,CZE
Authors and Affiliations
M. Sumanth*, T. Ramamohan Reddy, A. Ajitha, V. Uma MaheswaraRao
Keywords
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