Anti-nociceptive and anti-inflammatory activities of the extracts of Stauntonia chinensis
Journal Title: Pakistan Journal of Pharmaceutical Sciences - Year 2014, Vol 27, Issue 5
Abstract
The aim of this investigation was to study the anti-nociceptive and anti-inflammatory activities of Stauntonia chinensis (S. chinensis) and the possible action mechanisms of effective fractions. The anti-nociceptive and anti-inflammatory activities of S. chinensis extracts, including the 60% EtOH extract (YMG), the n-BuOH extract (YMGB) and the aqueous residue (YMGW) of YMG, and the fractions from YMGB (YMGB1~YMGB7) were investigated by using the mouse acetic acid-induced writhing test and the rat formalin test. The effect of these extracts on the PGE2 production was tested as well. In the mouse acetic acid-induced writhing test and the rat formalin test, YMGW and YMGB displayed anti-nociceptive and anti-inflammatory activities, suggesting that they were the active ingredients of YMG. Among the fractions isolated from YMGB, YMGB1, YMGB3, YMGB4 and YMGB6 were the main active ingredients producing anti-nociceptive activity and YMGB3, YMGB5, YMGB6 and YMGB7 were the main active ingredients producing anti-inflammatory activity. Additionally, YMGW, YMGB and its separations reduced the production of PGE2, which might be the mechanism of them producing anti-inflammatory activity. These results demonstrated the active ingredients of S. chinensis producing anti-nociceptive and anti-inflammatory activities, which is valuable to validate the substance basis of S. chinensis’s pharmacological actions.
Authors and Affiliations
Chen Ying , Wu Ning , Liu Ying , Gao Hao , Dong Hua-Jin , Su Rui-Bin , Yao Xin-Sheng , Li Jin
Keywords
Related Articles
- EP ID EP94568
- DOI -
- Views 120
- Downloads 0
Phytochemical analysis and estimation of major bioactive compounds from Triticum aestivum L. grass with antimicrobial potential
The aim of the present study was to investigate phytochemical analysis, and qualitative and quantitative determination of major bioactive compound present in various organic extracts of T. aestivum L. grass. Soxhle...
Clinical effects of immunotherapy of DC-CIK combined with chemotherapy in treating patients with metastatic breast cancer
This study aimed to analyze the clinical effects of dendritic cell (DC) and cytokine-induced killer (CIK) immunotherapy combined with chemotherapy on patients with metastatic breast cancer. Twenty patients were inc...
Role of Ki-67 in acromegalic patients with hyperprolactinemia: Retrospective analysis in 61 Chinese Patients
To evaluate the specific characteristics in acromegalic patients with hyperprolactinemia by analyzing the differences between patients with different Ki-67 values. Between 2002 and 2010, a set of data on 61 patient...
Study of the effect of inorganic and organic complexes of arsenic metal on the status of GSH in T. cells and B. cells of blood
Arsenic is a major threat to large part of the population due to its carcinogenic nature. The toxicity of Arsenic varies with its chemical form and oxidation states. Glutathione (GSH), a major intra-cellular tripep...
Potential antibacterial activity of coumarin and coumarin-3-acetic acid derivatives
Coumarin and coumarin-3-acetic acid derivatives were synthesized by reacting phenols with malic acid, ethyl acetoacetate and ethyl acetylsuccinate in appropriate reaction conditions. All synthesized compounds were...