Antidepressant activity of ethanolic extract of Hibiscus rosa sinenesis Linn.
Journal Title: Pakistan Journal of Pharmaceutical Sciences - Year 2014, Vol 27, Issue 5
Abstract
The present study was undertaken to assess the antidepressant effect of crude ethanolic extract of floral part of Hibiscusrosa sinensis (HRS) at doses 100mg/kg, 250mg/kg and 500mg/kg using three parameters which are forced induced swimming test (FST), tail suspension test (TST) and open field test(OFT). Flouxetine (15mg/kg, body weight) was used as standard. Significant dose dependent decline in immobility time was observed in all the three doses in FST and TST while in case of OFT none of the dose of HRS exhibited effectual results. To determine MAO”A” and MAO”B” activity HRS extract was used and the results revealed that each dose of this plant exhibited marked effect on MAO”A”, while on MAO”B” only 250mg/kg dose was found significant.
Authors and Affiliations
Leena Khalid , Ghazala H Rizwani , Viqar Sultana , Hina Zahid , Raheela Khursheed , Huma Shareef
Keywords
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