Antiproliferative xanthone derivatives from Calophyllum inophyllum and Calophyllum soulattri
Journal Title: Pakistan Journal of Pharmaceutical Sciences - Year 2015, Vol 28, Issue 2
Abstract
Structure-activity relationships of eleven xanthones were comparatively predicted for four cancer cell lines after the compounds were subjected to antiproliferative assay against B-lymphocyte cells (Raji), colon carcinoma cells (LS174T), human neuroblastoma cells (IMR-32) and skin carcinoma cells (SK-MEL-28). The eleven chemical constituents were obtained naturally from the stem bark of Calophyllum inophyllum and Calophyllum soulattri. Inophinnin (1) and inophinone (2) were isolated from Calophyllum inophyllum while soulattrin (3) and phylattrin (4) were found from Calophyllum soulattri. The other xanthones were from both Calophyllum sp. and they are pyranojacareubin (5), rheediaxanthone A (6), macluraxanthone (7), 4-hydroxyxanthone (8), caloxanthone C (9), brasixanthone B (10) and trapezifolixanthone (11). Compound 3 was found to be the most cytotoxic towards all the cancer cell lines with an IC50 value of 1.25µg/mL while the simplest xanthone, compound 8 was inactive.
Authors and Affiliations
Siau Hui Mah , Gwendoline Cheng Lian Ee , Soek Sin Teh , Mohd Aspollah Sukari
Keywords
Related Articles
- EP ID EP116665
- DOI -
- Views 98
- Downloads 0
Synthesis, Spectral investigation (1H, 13C) and Anti-microbial Screening of benzophenone imines
New series of benzophenone imines with general formula Ph2-C=NR; R = Benzyl, 4-Fluorobenzyl, Naphthyl, Phenyl, 4-Nitrophenyl were synthesized by condensation of dichlorodiphenylmethane and different aromatic primar...
Therapeutic effects of total alkaloids of Fructus Hordei Germinatus in hyperprolactinemis rats
Fructus Hordei Germinatus is widely used in treating hyperprolactinemia as a kind of Chinese traditional herb in China. However, its active composition of curing hyperprolactinemia remains unclear. This study investigate...
Determination of pKa values of new phenacyl-piperidine derivatives by potentiometric titration method in aqueous medium at room temperature (25±0.5oC)
Dissociation constant (pKa) of ten novel phenacyl derivatives of piperidine were determined by potentiometric titration method in aqueous medium at room temperature (25 ±0.5oC). The sample solutions were prepared i...
Prophylactic role of B vitamins against bulk and zinc oxide nano-particles toxicity induced oxidative DNA damage and apoptosis in rat livers
The aim of this work is to explore the protective of B vitamins (B3, B6 and B12) against the hepatotoxic potency of either bulk zinc oxide (ZnO-bulk) or its nanoparticles (ZnO-NPs)-induced liver damage in rats. ZnO...
[sup][/sup] In vitro dissolution and physicochemical characterizations of novel PVP-based solid dispersions containing valsartan prepared by a freeze-drying method
Valsartan (VAL) shows poor oral bioavailability mainly as a result of its low water solubility at low pH. This study is designed to investigate the dissolution properties and physicochemical characteristics of nove...