Assessment of rosmarinic acid content in six Lamiaceae species extracts and their antioxidant and antimicrobial potential
Journal Title: Pakistan Journal of Pharmaceutical Sciences - Year 2015, Vol 28, Issue 6
Abstract
In the present study, six indigenous species of Lamiaceae family (Origanum vulgare L., Melissa officinalis L., Rosmarinus officinalis L., Ocimum basilicum L., Salvia officinalis L. and Hyssopus officinalis L.), have been analyzed to assess the rosmarinic acid, phenyl propane derivatives and polyphenolic contents and their antioxidant and antimicrobial potential. HPLC-MS method has been used for the analysis ofrosmarinicacid. The phenyl propane derivatives and total phenolic contents were determined using spectrophotometric method. The ethanolic extracts were screened for antioxidant activities by DPPH radical scavenging, HAPX (hemoglobin ascorbate per oxidase activity inhibition), and EPR (electron paramagnetic resonance) methods. The ethanolic extracts revealed the presence of rosmarinic acid in the largest amount in O. vulgare (12.40mg/g) and in the lowest in R. officinalis (1.33 mg/g). O. vulgare extracts exhibited the highest antioxidant capacity, in line with the rosmarinic acid and polyphenolic contents. The antimicrobial testing showed a significant activity against L. monocytogenes, S. aureus and C. albicans for all six extracts.
Authors and Affiliations
Daniela Benedec , Daniela Hanganu , Ilioara Oniga , Brindusa Tiperciuc , Neli-Kinga Olah , Oana Raita , Cristina Bischin , Radu Silaghi-Dumitrescu , Laurian Vlase
Keywords
Related Articles
- EP ID EP122896
- DOI -
- Views 97
- Downloads 0
Effect of repeated oral therapeutic doses of methylphenidate on food intake and growth rate in rats
Central nervous system stimulants are known to produce anorexia. Previous data suggest that methylphenidate can have variable effects on caloric intake and growth rate. A dose-response study was performed to monito...
Diagnosis and clinical observation of lactose-free milk powder on treatment of neonatal diarrhea
Neonatal lactose intolerance syndrome is a series of digestive system symptoms caused by the lack of lactase, and could not fully digest the lactose in breast milk or cow milk. Lactose is one of the disaccharides m...
In vivo evaluation & safety profile evaluation of Arctostaphylos uva-ursi (L.) Spreng. extract in rabbits
The aim of our research work was to investigate the effects of low dose of Arctostaphylos uva-ursi (L.) Spreng. on rabbits. Crude extract was administered for 90 days in rabbits and hematology, biochemistry paramet...
Study of the effect of inorganic and organic complexes of arsenic metal on the status of GSH in T. cells and B. cells of blood
Arsenic is a major threat to large part of the population due to its carcinogenic nature. The toxicity of Arsenic varies with its chemical form and oxidation states. Glutathione (GSH), a major intra-cellular tripep...
Vasorelaxant effect of essential oil isolated from Nigella sativa L. seeds in rat aorta: Proposed mechanism
The effect of the essential oil extracted from Nigella sativa (L.) seeds (Nigella oil) was investigated for its vasorelaxant activity on isolated rat aorta. Nigella oil at concentrations of 10-100µg/mL elicited a d...