Chitosan-modified superparamgnetic iron oxide nanoparticles: design, fabrication, characterization and antibacterial activity
Journal Title: CHEMIK nauka-technika-rynek - Year 2015, Vol 69, Issue 1
Abstract
The goal of this study was to develop an antibacterial activity system. To this end, we prepared using co-precipitation method a biocompatible nanocomposite: superparamagnetic iron oxide nanoparticles – chitosan. The morphological and magnetic properties of the nanocomposite were characterized by different techniques. At room temperature, the samples exhibit superparamagnetic behavior with the saturation magnetization of 65emu/g for coated nanoparticles. For checking its efficiency in inhibition of human pathogen, the yielded nanocomposite was used in antibacterial assay. The synthesized colloids and thin films have potent and completely strong antibacterial activity toward gram-negative bacteria Pseudomonas aeruginosa and Escherichia coli in comparison with superparamagnetic iron oxide nanoparticles which have less strong antibacterial activity. The concentration of Fe3O4 leading to a complete inhibition of bacteria growth was revealed at as low as at 40 μ g.ml-1 for Pseudomonas aeruginosa and 45 μ g.ml-1 for Escherichia coli. Thus superparamagnetic iron oxide nanoparticles – chitosan biocompatible nanocomposite could be suitable for antimicrobial applications and medical devices.
Authors and Affiliations
A. Shrifian-Esfahni, M. T. Salehi, M. Nasr-Esfahni, E. Ekramian
Keywords
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