CHRONOTHERAPY: A CONCEPT, PAUPERISM AND APPROCHES
Journal Title: International Journal of Pharmaceutical Development & Technology - Year 2011, Vol 1, Issue 1
Abstract
In the modern era of treatment many new approaches have been evolved for more efficient administration of drugs. Oneof such approach is the administration of drugs at times at which they are most effective and best tolerated. Chronotherapy is theapproach where the availability of drug is timed to match rhythms of disease or disorders in order to optimize therapeuticresponses and minimize side effects, which makes it a profound and purposeful delivery of medications in unequal amounts overtime. Number of systems such as pulsatile drug delivery systems which can use stimuli from magnetic, electric, ultrasound,chemicals, enzymes etc. for drug release in the form of pulse when actually required, core in cup tablets, compressioncoated/press coated tablets, double coated hard gelatin capsules and double coated tablets, chronomodulating infusion pumps,controlled-release microchip, Layered systems, sigmoidal release systems hydrogels, osmotic drug delivery systems etc havebeen successfully used for effective chronotherapeutic drug delivery systems.
Authors and Affiliations
R. V. Trivedi , K. J. Wadher , J. B. Taksande , J. G. Mahore , M. J. Umekar
Keywords
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