Comparison of Effectiveness Profile of Danazol and Gestrinone in Pelvic Endometriosis: A Community Based Observational Study in Wardha District-Eastern Maharashtra
Journal Title: IOSR Journal of Pharmacy (IOSRPHR) - Year 2015, Vol 5, Issue 1
Abstract
BACKGROUND: Endometriosis is the presence of functioning endometrial tissue outside the uterus and most commonly affects women in the reproductive age group. The present study was conducted to evaluate the effectiveness of Danazol and Gestrinone, steroidal androgenic drugs in the treatment of women with Pelvic Endometriosis in a District of Central India.METHODS: From a period of January 2008 to March 2014 we got 282 women with laparoscopically confirmed diagnosis of Pelvic Endometriosis who were treated with either Danazol or Gestrinone. Out of which 154 were treated with Danazol and 128 were treated with Gestrinone.. Disease severity was measured by calculating the Total symptom severity score using the Biberoglu and Behrman scale at diagnosis and after 90 and 180 days of treatment. Effectiveness was assessed by mean changes in Total symptom severity score after 90 days and 180 days of treatment from the baseline for Danazol and Gestrinone and compared. RESULTS: All demographic and baseline factors were comparable in Danazol and Gestrinone treated groups. Both Danazol and Gestrinone satisfactorily resolved Dysmenorhhoea, Dyspareunia, Pelvic Discomfort, Pelvic Induration and Pelvic Tenderness from baseline. No significant difference were noted in effectiveness endpoints between Danazol and Gestrinone treated groups regarding Total symptom severity score after 90 days and 180 days.CONCLUSION: Both Danazol and Gestrinone demonstrated similar clinical effectiveness. But it was observed that Danazol is more commonly prescribed then Gestrinone but has more secondary and GI intolerant side effects. However Prospective interventional study is required to confirm the efficacy of the both drugs.
Authors and Affiliations
Thaim SA , Jha RK, Saheta A, Santra D, SamaThaim S
Keywords
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