Compatibility and stability of polygeline (Haemaccel) with different drug products
Journal Title: Pakistan Journal of Pharmaceutical Sciences - Year 2014, Vol 27, Issue 6
Abstract
Compatibility and stability of the polygeline-based blood plasma expander/plasma substitute Haemaccel with different drug products i.e., Profenid, Stemetil, and Lasix were examined in the context of its potential use in surgical, spinal, septic shock and in circulatory insufficiency, because treatment, safety, acceptability and efficacy of drug product may be affected by drug instability or incompatibility. Therefore, drug stability and compatibility are critical elements in accurate and appropriate delivery of drug therapy to patients. This study was initiated to specifically and critically assess the compatibility of Haemaccel with different drug products with the aim of delivering safe, suitable, acceptable and efficacious administration of two different drug products simultaneously in emergency conditions. All of these different brands of drug products were physically and chemically compatible with Haemaccel and all of the test results were almost similar before and after mixing different drugs in Haemaccel. This study revealed that Lasix, Profenid and Stemetil can be administered/co-administered with Haemaccel safely. Different drug product must be studies in detail before it’s co-administration with Haemaccel.
Authors and Affiliations
Mansoor Ahmad , Nudrat Adil
Keywords
Related Articles
- EP ID EP100548
- DOI -
- Views 93
- Downloads 0
The Fructose mystery: How bad or good is it?
This review article endeavoured to ascertain the facts about fructose, a mono-saccharide sugar being increasingly used in daily diet. Human and animal studies suggest that fructose ingestion produces deleterious effects...
Isolation and characterization of a new oxygenated homoditerpenoid from leaves of Centaurothamnus maximus with antimicrobial potential
A new bioactive oxygenated homoditerpenic compound along with one known compound from the antimicrobial active ethanol extract of leaves of an endemic plant Centaurothamnus maximus was isolated. The n -hexane, dich...
Dimethyl 3, 3’, 4, 4’-tetrahydroxy-δ-truxinate isolated from the leavesof Andrographis lineata.Wall. ex. Nees suppress adipogenesis in 3T3-L1preadipocytes for type 2 diabetes
The present investigation elucidates the isolation and characterization of bioactive compound from the ethanolic leaf extract of Andrographis lineata (EtALL) which suppress the differentiation of 3T3-L1 adipocytes....
Role of the antidiabetic drugs: Glibenclamide and metformin on the contractility of isolated rat uteri
The current investigation has designed to study the role of two antidiabetics, glibenclamide and metformin on the spontaneous uterine contractions in the non-diabetic non-pregnant female rats. The rat uteri were is...
Clinical effects of immunotherapy of DC-CIK combined with chemotherapy in treating patients with metastatic breast cancer
This study aimed to analyze the clinical effects of dendritic cell (DC) and cytokine-induced killer (CIK) immunotherapy combined with chemotherapy on patients with metastatic breast cancer. Twenty patients were inc...