Correlation of Serial Beta Hcg Titre And Ca125 Estimation In Predicting Early Pregnancy Failure
Journal Title: IOSR Journal of Pharmacy (IOSRPHR) - Year 2015, Vol 5, Issue 1
Abstract
OBJECTIVE : To assess the diagnostic value of maternal CA 125 in patients with first trimester pregnancy and to evaluate the prognostic significance of CA 125 versus β-hCG in early pregnancies with intact fetal heartbeat, complicated by vaginal bleeding. . STUDY DESIGNSETTING : The study was conducted at Dept. of O&G and Biochemistry of institute of post graduate medical education & research,Kolkata.Control patients were 30 pregnant women who had normal pregnancy without complications.Fifty patients with vaginal bleeding during gestational weeks 6-12 all of whom having demonstrable foetal heart beat were studied.17 patients finally aborted whereas the reminder 33 had normal pregnancy continued till term. Measurement of serum CA 125 &Beta HCG were carried out at department of Biochemistry, IPGME&R. MAIN OUTCOME MEASURE: 2 sequential measurements of serum CA125 and beta HCG performed within a 5-7 days interval were related to the outcome of pregnancy as indicated by changes of the ultrasound presentation,miscarriage etc.RESULTS Initial CA 125 levels did not differ significantly between both groups of patients with 33/50 nonaborters and 17/50 aborters showing concentrations below 60 IU/ml. After 48-72 hrs, CA 125 in all patients who eventually aborted remained high or increased whereas non-aborters all had constantly low or declining CA 125 measures. β-hCG increased in all non-aborters and also in aborters during the 2-3 day interval.CONCLUSION: Sequential determinations of maternal CA 125 measurements appear to be a highly sensitive prognostic marker in patients with viable pregnancy at risk for abortion whereas serum beta hcg did not show any significant change during that period.
Authors and Affiliations
Dr. Aruna Bhattacharya , Dr. sumit Ranjan Pramanik , Dr. Rama Saha , Dr. Bhaswati das , Oishee Maya Sen
Keywords
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