DESIGN AND IN-VITRO-IN-VIVO CHARACTERIZATION OF BUCCAL TABLETS OF SIMVASTATIN
Journal Title: Asian J of Pharm Sci & Tech - Year 2015, Vol 5, Issue 3
Abstract
ABSTRACT The main objective of present study is to develop Bucco adhesive bilayer tablets of Simvastatin using mucoadhesive polymers. Simvastatin has short biological half-life (3h), high first-pass metabolism and poor oral bioavailability (5%), hence an ideal candidate for buccal delivery system. The tablets were prepared by direct compression technique using carbopol-934, sodium carboxy methyl cellulose (Na CMC), Poly vinyl pyrollidine (PVP) and hydroxyl propyl methyl cellulose (HPMC) as mucoadhesive polymers. Soyabean powder is mainly used as a diluent in this formulation as it contain less fats and more protein substances. Formulations were evaluated for weight variation, hardness, friability, drug content, swelling studies, surface pH, bioadhesion strength, invitro drug release, ex-vivo permeation studies, using sheep buccal mucosa, muco irritation test, in-vitro release studies, in-vivo studies, IVIVC and stability studies. Formulation S11 exhibited controlled drug release at (11h) containing polymers like HPMC K100M, carbopol934P and PVP K30. Formulation S11 selected as optimized formulation based on physicochemical parameters and ex-vivo permeation studies and follows zero order drug release. FTIR studies show no evidence on interaction between drug, polymers and other excipients. The results indicate that Simvastatin is a suitable candidate when given through the buccal drug delivery. Key words: Mucoadhesion, Simvastatin, swelling index, buccal drug delivery.
Authors and Affiliations
M. Alagusundaram*, S. Angalaparameswai, M. Padmavathamma
Keywords
Related Articles
- EP ID EP90883
- DOI -
- Views 262
- Downloads 0
COMPARATIVE DIVERSITY PROFILES OF GASTRO INTESTINAL MICRO FLORA OF NORMAL AND SICK “OREOCHROMIS MOSSAMBICUS” (PETERS)
ABSTRACT Oreochromis mossambicus (Peters) is a commercially important edible fish. It can be used to augment food protein and study of gut of “Oreochromis mossambicus”. The present study aims at the investigation...
GC-MS EVALUATION OF BIOACTIVE MOLECULES FROM THE METHANOLIC LEAF EXTRACT OF AZADIRACHTA INDICA (A.JUSS).
ABSTRACT Azadirachta indica A.Juss., has a long history of medicinal usage in the treatment of various chronic diseases.The present study was undertaken to explore the potential bioactive components present in th...
ASSESSMENT OF ANTIOXIDANT PROPERTY OF QUISQUALIS INDICA
ABSTRACT The methanolic crude extracts of Quisqualis indica flower was used for their free radical scavenging properties using ascorbic acid as standard antioxidant. The antioxidant activities of Quisqualis indic...
TARGET ORGAN DETERMINATION FOR AYURVEDA DRUGS (TODAyD) – A NOVEL EVIDENT MODEL FOR WHOLISTIC AYURVEDIC DRUG SUGGESTED IN THE STUDY OF SUKROTPADAKAKARMA
ABSTRACT All chemical drugs are usually mono molecular. The composition of the molecule is clearly known. Being a single molecule it spreads rapidly, reach the target organ and exhibit the effect. Animal experime...
TABLETING PROPERTIES OF THERMALLY ACTIVATED COW BONE POWDER IN LOW DOSE FORMULATION
ABSTRACT Formulations of low dose drugs into a tablet dosage form require appropriate diluents in a significant quantity that may enhance the ease of handling. Activated cow bone powder was evaluated and found su...