EFFECT OF EXCIPIENTS AND PROCESS VARIABLES OVER GASTRO RETENTIVE ANTIHYPERTENSIVE DOSAGE FORM
Journal Title: Int J of Preclin & Pharm Res - Year 2014, Vol 4, Issue 3
Abstract
ABSTRACT The objective of this study was to formulate an oral floating tablet of Captopril using the hydrophilic polymer hydroxy propyl methyl cellulose (HPMC) and Carbopol 934P gas generating agent Calcium Carbonate and citric acid using direct compression method. The prepared tablets were evaluated in terms of their physical characteristics, in vitro release, buoyancy, buoyancy lag-time and swelling index. The results of all the pre and post compression tests of all formulations batches were found to be sympathetic. The in-vitro % drug release was found to be in range of 79.99 to 97.23 % at the end of 24 hrs. From the in-vitro dissolution study it was observed that tablet of batch F6 showed highest percentage cumulative drug release due to combination of HPMC K100M, HPMC K15M and carbopol selected as optimized batch. Optimized batch was further evaluated for the effect of dissolution apparatus USP type I and type II and hardness of tablet. The USP Type I apparatus suppresses the three dimensional drug releases from the matrix tablet. The tablet having higher hardness affects the floating lag time and also retards the drug release from the matrix.The n value obtained from the korsemeyer-peppas equation indicates tablet of batch F6 shows rather first order release mechanism. Keywords: Floating Tablet, Hardness, HPMC, Carbopol 934P, Dissolution Apparatus.
Authors and Affiliations
Umesh T Jadhao*, Vinod M Thakare,Bharat WTekade, Kundan P Chaudhari, Chetan S Chaudhari
Keywords
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